Tsai I-Chen, Hsu Chih-Wei, Chang Chun-Hung, Tseng Ping-Tao, Chang Ke-Vin
Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Congenital Heart Disease Study Group, Asian Society of Cardiovascular Imaging, Seoul, Korea.
Front Pharmacol. 2022 Aug 24;13:883251. doi: 10.3389/fphar.2022.883251. eCollection 2022.
Coenzyme Q10 (CoQ10) is a popular nutritional supplement, an antioxidant and an essential component of the mitochondrial electron transport chain. Several clinical studies have suggested that fatigue can be reduced by antioxidant supplementation. However, the data on this topic has been sparse to date. Hence, we conducted this meta-analysis with the aim of investigating the effectiveness of fatigue reduction via CoQ10 supplementation. More specifically, we searched electronic databases for randomized controlled trials (RCTs) published from the database inception to January 2022. A random effects model was implemented to conduct the meta-analysis among 13 RCTs (with a total of 1,126 participants). As compared with the placebo groups evaluated in each RCT, the CoQ10 group showed a statistically significant reduction in fatigue scores (Hedges' = -0.398, 95% confidence interval = -0.641 to -0.155, = 0.001). The directions of the treatment effects were consistent between the healthy and diseased participants. Compared with the placebo group, the effect of reducing fatigue was statistically significant in the subgroup using the CoQ10-only formulation but not in the subgroup using CoQ10 compounds. The results of our meta-regression demonstrate that increases in the daily dose (coefficient = -0.0017 per mg, < 0.001) and treatment duration (coefficient = -0.0042 per day, = 0.007) of CoQ10 supplementation were correlated with greater fatigue reduction. There was only one adverse (gastrointestinal) event in the 602 participants who underwent the CoQ10 intervention. Based on the results of this meta-analysis, we conclude that CoQ10 is an effective and safe supplement for reducing fatigue symptoms. https://inplasy.com/inplasy-2022-1-0113/, identifier INPLASY202210113.
辅酶Q10（CoQ10）是一种广受欢迎的营养补充剂，具有抗氧化作用，是线粒体电子传递链的重要组成部分。多项临床研究表明，补充抗氧化剂可减轻疲劳。然而，迄今为止，关于这一主题的数据较为稀少。因此，我们进行了这项荟萃分析，旨在研究补充CoQ10减轻疲劳的有效性。更具体地说，我们检索了电子数据库，查找从数据库建立到2022年1月发表的随机对照试验（RCT）。采用随机效应模型对13项RCT（共1126名参与者）进行荟萃分析。与各RCT中评估的安慰剂组相比，CoQ10组的疲劳评分在统计学上显著降低（Hedges' = -0.398，95%置信区间 = -0.641至-0.155， = 0.001）。健康参与者和患病参与者的治疗效果方向一致。与安慰剂组相比，仅使用CoQ10制剂的亚组减轻疲劳的效果在统计学上显著，而使用CoQ10化合物的亚组则不然。我们的荟萃回归结果表明，CoQ10补充剂的每日剂量增加（系数 = -0.0017每毫克， < 0.001）和治疗持续时间增加（系数 = -0.0042每天， = 0.007）与更大程度的疲劳减轻相关。在接受CoQ10干预的602名参与者中，仅发生了1例不良（胃肠道）事件。基于这项荟萃分析的结果，我们得出结论，CoQ10是一种减轻疲劳症状的有效且安全的补充剂。https://inplasy.com/inplasy-2022-1-0113/，标识符INPLASY202210113 。
