Egawa S, Hiwatashi N
J Clin Lab Immunol. 1986 Aug;20(4):187-92.
It has been suggested that the "natural killer" (NK) cell may play an important role in immune surveillance against tumors and viral-infected cells. With the use of 51Cr-labeled K-562 as target cells, we assessed natural killer cell activity in patients with inflammatory bowel disease (IBD). In ulcerative colitis (UC) patients' NK cell activity in the remissive and active stages was not significantly different with normal controls. In Crohn's disease (CD) patients' NK cell activity was significantly below normal levels in both remissive and active stages. Furthermore, in the active stage NK cell activity was significantly lower than that in the remissive stage in CD patients. Using the anti-Leu-11a monoclonal antibody, we quantified the number of circulating NK cells in CD patients. Decreased NK activity in CD patients is most likely not the consequence of diminished numbers of NK cells or of maturational defects of NK precursor cells. Macrophage seems to be one of the factors related to decreased NK cell activity. Further, impairment of NK cell activity in CD patients is reversible. It is possible that NK cell activity in CD patients recovers to the normal level.
有人提出，“自然杀伤”（NK）细胞可能在针对肿瘤和病毒感染细胞的免疫监视中发挥重要作用。我们使用51Cr标记的K-562作为靶细胞，评估了炎症性肠病（IBD）患者的自然杀伤细胞活性。在溃疡性结肠炎（UC）患者中，缓解期和活动期的NK细胞活性与正常对照组无显著差异。在克罗恩病（CD）患者中，缓解期和活动期的NK细胞活性均显著低于正常水平。此外，在活动期，CD患者的NK细胞活性显著低于缓解期。我们使用抗Leu-11a单克隆抗体对CD患者循环NK细胞的数量进行了定量。CD患者NK活性降低很可能不是NK细胞数量减少或NK前体细胞成熟缺陷的结果。巨噬细胞似乎是与NK细胞活性降低相关的因素之一。此外，CD患者NK细胞活性的损害是可逆的。CD患者的NK细胞活性有可能恢复到正常水平。
