de Andrade Caio Leônidas Oliveira, Machado Gabriela Carvalho, Magalhães Luan Paulo Franco, Pereira de Jesus Elen, Alves Matias Elaine, de Oliveira Cerqueira Taíse Lima, de Oliveira Hélida Braga, da Cruz Fernandes Luciene, Ramos Helton Estrela, de Aragão Dantas Alves Crésio
Postgraduate Program in Interactive Processes of Organs and Systems, Institute of Health Science- Federal University of Bahia, Avenue Rector Miguel Calmon, Valley of Canela, 40110100, Salvador, Bahia, Brazil.
Department of Life Sciences, University of the State of Bahia, Street Silveira Martins, Cabula, 41150000, Salvador, Bahia, Brazil.
J Otol. 2019 Mar;14(1):6-11. doi: 10.1016/j.joto.2018.11.007. Epub 2018 Nov 20.
To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism patients.
An analytical, quantitative, cross-sectional exploratory study with a 1:1 ratio, consisting of a convenience sample of 86 normal hearing individuals with (n = 42) and without (n = 44) congenital hypothyroidism diagnosis. All participants underwent tonal and speech audiometry, immitance and distortion product otoacoustic emissions. The researchers excluded people with hearing loss, genetic syndromes and metabolic diseases. The instrument used for evaluate of self-reported participation restrictions was the HHIE-adapted questionnaire, composed of 25 questions, 12 of which were social domain and 13 emotional domain. Student's t-test and chi-square test were used for statistical analysis at a significance level of 5%.
There was a significant (p < 0.001) self-reported participation restrictions in CH (61.9%), with a greater relevance for the social domain (p = 0.002). There was a greater frequency of mild/moderate (40.5%) and higher prevalence of association with clinical factors and adherence to treatment.
The findings indicate that self-reported participation restrictions in normal hearing individuals with congenital hypothyroidism was more significant than in the non-exposed group, suggesting evidence of subclinical auditory abnormalities in this population.
通过自我报告的参与限制来验证正常听力个体和先天性甲状腺功能减退症患者亚临床改变的证据。
一项分析性、定量、横断面探索性研究，比例为1:1，由86名正常听力个体组成的便利样本构成，其中有先天性甲状腺功能减退症诊断的（n = 42）和无先天性甲状腺功能减退症诊断的（n = 44）。所有参与者均接受了纯音及言语听力测试、声导抗测试和畸变产物耳声发射测试。研究人员排除了有听力损失、遗传综合征和代谢疾病的人。用于评估自我报告的参与限制的工具是改编后的HHIE问卷，由25个问题组成，其中12个属于社会领域，13个属于情感领域。采用学生t检验和卡方检验进行统计分析，显著性水平为5%。
先天性甲状腺功能减退症患者自我报告的参与限制显著（p < 0.001），为61.9%，在社会领域相关性更大（p = 0.002）。轻度/中度的频率更高（40.5%），与临床因素及治疗依从性相关的患病率也更高。
研究结果表明，先天性甲状腺功能减退症的正常听力个体自我报告的参与限制比未暴露组更显著，提示该人群存在亚临床听觉异常的证据。
