Tamimi F, Wu X
1 Faculty of Dentistry, McGill University, Montreal QC, Canada.
JDR Clin Trans Res. 2017 Jul;2(3):211-213. doi: 10.1177/2380084417701897. Epub 2017 Mar 24.
The process of osseointegration around dental implants is similar to the biological events occurring during bone repair and fracture healing. Therefore, bone metabolic activity plays a crucial role on the success of osseointegration, and dysregulation of bone metabolism can have a negative impact on bone healing and implant osseointegration. Accordingly, it could be hypothesized that drugs interfering with healing and bone metabolism could affect osseointegration and implant survival. Looking into the relationship between pharmacology, osseointegration, and dental implants, drugs can open the door for new pharmacological innovations to improve implant success and avoid unnecessary complications, and it is also of special interest because most implant patients are elder adults who are often polymedicated. In this commentary, we discuss the discoveries made by us as well as by other researchers regarding the effect of several drugs on bone, osseointegration, and implant survival. Of particular interest is the growing evidence showing that commonly used drugs such as nonsteroidal anti-inflammatories, serotonin reuptake inhibitors, and proton pump inhibitors could lead to implant failure.
牙种植体周围的骨结合过程类似于骨修复和骨折愈合期间发生的生物学事件。因此，骨代谢活动对骨结合的成功起着至关重要的作用，而骨代谢失调会对骨愈合和种植体骨结合产生负面影响。相应地，可以推测干扰愈合和骨代谢的药物可能会影响骨结合和种植体存活。研究药理学、骨结合和牙种植体之间的关系，药物可以为新的药理学创新打开大门，以提高种植成功率并避免不必要的并发症，这也特别值得关注，因为大多数种植患者是老年人，他们经常同时服用多种药物。在这篇评论中，我们讨论了我们以及其他研究人员关于几种药物对骨、骨结合和种植体存活影响的发现。特别值得关注的是越来越多的证据表明，常用药物如非甾体抗炎药、5-羟色胺再摄取抑制剂和质子泵抑制剂可能导致种植失败。
