Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Department of Obstetrics and Gynecology, Division of Gynecological Endocrinology and Reproductive Medicine, Medical University of Graz, Auenbruggerplatz 14, 8036, Graz, Austria.
Clin Nutr. 2020 Mar;39(3):718-726. doi: 10.1016/j.clnu.2019.03.007. Epub 2019 Mar 20.
BACKGROUND & AIMS: Vitamin D supplementation may affect glycemic as well as hormonal regulation. Thus, the aim of the current study was to investigate whether vitamin D supplementation has any significant effects on metabolic and endocrine parameters in healthy premenopausal women. Primary outcome measure was the plasma glucose area under the curve (AUCgluc).
The current study was a single-center, double-blind, randomized placebo-controlled trial that was conducted at the Medical University of Graz, Austria, between March 2013 and October 2017. One-hundred and fifty healthy premenopausal women with 25-hydroxyvitamin D [25(OH)D] concentrations <75 nmol/L once weekly received either 20,000 IU of cholecalciferol or placebo (2:1 ratio) over a total of 24 weeks.
In total, 127 women [age 36.2 ± 8.7 years; BMI 25.3 ± 5.6 kg/m; baseline 25(OH)D 55.8 ± 19.7 nmol/L] completed the study. Vitamin D supplementation had no significant effect on AUCgluc (mean treatment effect 11.70; p = 0.069), while it had a significant treatment effect on homeostatic model assessment-insulin resistance (HOMA-IR; mean treatment effect 0.31; p = 0.019) and quantitative insulin-sensitivity check index (QUICKI; mean treatment effect -0.019; p = 0.013). There was no significant effect on the remaining secondary outcome parameters.
In this randomized-controlled trial in healthy premenopausal women, there was a significant treatment effect of vitamin D supplementation on HOMA-IR and QUICKI, while there was no significant treatment effect on AUCgluc.
维生素 D 补充可能会影响血糖和激素调节。因此，本研究的目的是调查维生素 D 补充是否对健康绝经前妇女的代谢和内分泌参数有任何显著影响。主要观察指标是血浆葡萄糖曲线下面积（AUCgluc）。
本研究是一项在奥地利格拉茨医科大学进行的单中心、双盲、随机安慰剂对照试验，于 2013 年 3 月至 2017 年 10 月进行。150 名 25-羟维生素 D [25（OH）D]浓度<75 nmol/L 的健康绝经前妇女每周一次接受 20,000 IU 胆钙化醇或安慰剂（2:1 比例），共 24 周。
共有 127 名女性[年龄 36.2±8.7 岁；BMI 25.3±5.6 kg/m；基线 25（OH）D 55.8±19.7 nmol/L]完成了研究。维生素 D 补充对 AUCgluc 没有显著影响（平均治疗效果 11.70；p=0.069），但对稳态模型评估-胰岛素抵抗（HOMA-IR；平均治疗效果 0.31；p=0.019）和定量胰岛素敏感性检查指数（QUICKI；平均治疗效果-0.019；p=0.013）有显著的治疗效果。其余次要观察指标无显著影响。
在这项健康绝经前妇女的随机对照试验中，维生素 D 补充有显著的治疗效果，可降低 HOMA-IR 和 QUICKI，但对 AUCgluc 无显著影响。
