Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Division of Obstetrics, Department of Obstetrics and Gynecology, Medical University of Graz, Auenbruggerplatz 14/1, 8036 Graz, Austria.
Nutrients. 2019 Aug 14;11(8):1894. doi: 10.3390/nu11081894.
Vitamin D might play a role in metabolic processes and obesity. We therefore examined vitamin D effects on metabolic markers and obesity in a randomized controlled trial (RCT). This is a post-hoc analysis of the Graz Vitamin D&TT-RCT, a single-center, double-blind, randomized placebo-controlled trial. We included 200 healthy men with serum 25-hydroxyvitamin D (25(OH) D) levels <75 nmol/L. Subjects received 20,000 IU of vitamin D3/week ( = 100) or placebo ( = 100) for 12 weeks. Outcome measures were metabolic markers, anthropometric measures, and body composition assessed by Dual-energy X-ray absorptiometry. One-hundred and ninety-two men completed the study. We found a significant treatment effect on fasting glucose/fasting insulin ratio (-5.3 (-10.4 to -0.2), = 0.040), whereas we observed no significant effect on the remaining outcome parameters. In subgroup analyses of men with baseline 25(OH)D levels <50 nmol/L ( = 80), we found a significant effect on waist circumference (1.6 (0.3 to 2.9) cm, = 0.012), waist-to-hip ratio (0.019 (0.002 to 0.036), = 0.031), total body fat (0.029 (0.004 to 0.055) %, = 0.026), and android fat (1.18 (0.11 to 2.26) %, = 0.010). In middle-aged healthy men, vitamin D treatment had a negative effect on insulin sensitivity. In vitamin D deficient men, vitamin D has an unfavorable effect on central obesity and body composition.
维生素 D 可能在代谢过程和肥胖中发挥作用。因此，我们在一项随机对照试验（RCT）中研究了维生素 D 对代谢标志物和肥胖的影响。这是格拉茨维生素 D&TTRCT 的事后分析，这是一项单中心、双盲、随机安慰剂对照试验。我们纳入了 200 名血清 25-羟维生素 D（25(OH)D）水平<75nmol/L 的健康男性。受试者每周接受 20,000IU 的维生素 D3（=100）或安慰剂（=100）治疗 12 周。主要结局指标为代谢标志物、人体测量指标和双能 X 线吸收法评估的身体成分。192 名男性完成了研究。我们发现空腹血糖/空腹胰岛素比值有显著的治疗效果（-5.3[-10.4 至-0.2]，=0.040），而其余结局参数未见显著影响。在基线 25(OH)D 水平<50nmol/L 的男性亚组分析中（=80），我们发现腰围（1.6[0.3 至 2.9]cm，=0.012）、腰臀比（0.019[0.002 至 0.036]，=0.031）、全身脂肪（0.029[0.004 至 0.055]%，=0.026）和腹部脂肪（1.18[0.11 至 2.26]%，=0.010）有显著影响。在中年健康男性中，维生素 D 治疗对胰岛素敏感性有负面影响。在维生素 D 缺乏的男性中，维生素 D 对中心性肥胖和身体成分有不利影响。
