Section of Bone Marrow Transplant and Cellular Therapy, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, 1725 West Harrison Street, Suite 809, Chicago, IL 60612, USA.
Section of Bone Marrow Transplant and Cellular Therapy, Division of Hematology, Oncology and Cell Therapy, Rush University Medical Center, 1725 West Harrison Street, Suite 809, Chicago, IL 60612, USA.
Infect Dis Clin North Am. 2019 Jun;33(2):331-359. doi: 10.1016/j.idc.2019.01.002. Epub 2019 Mar 30.
This article discusses the complications of hematopoietic stem cell transplantion (HSCT) that affect infections in HSCT recipients, with analogies to patients with hematologic malignancies. Mucositis, with mucosal barrier disruption, is common and increases the risk of gram-positive and anaerobic bacterial, and fungal infections, and can evolve to typhlitis. Engraftment syndrome; graft-versus-host disease, hepatic sinusoidal obstruction syndrome; and posterior reversible encephalopathy syndrome can affect the infectious potential either directly from organ dysfunction or indirectly from specific treatment. Pulmonary infections can predispose to life threatening complications including diffuse alveolar hemorrhage, idiopathic pulmonary syndrome, bronchiolitis obliterans syndrome, and bronchiolitis obliterans with organizing pneumonia.
本文讨论了造血干细胞移植（HSCT）的并发症，这些并发症会影响 HSCT 受者的感染，与血液系统恶性肿瘤患者类似。黏膜炎伴有黏膜屏障破坏很常见，增加了革兰阳性和厌氧细菌以及真菌感染的风险，并可发展为 typhlitis。植入综合征；移植物抗宿主病、肝窦阻塞综合征；和可逆性后部脑病综合征可直接因器官功能障碍或间接因特定治疗而影响感染的可能性。肺部感染可导致危及生命的并发症，包括弥漫性肺泡出血、特发性肺综合征、闭塞性细支气管炎综合征和闭塞性细支气管炎伴机化性肺炎。
