Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Department of Host Defense and Biochemical Research, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
Int J Biol Macromol. 2019 Jul 1;132:795-800. doi: 10.1016/j.ijbiomac.2019.03.234. Epub 2019 Mar 30.
It has been reported that cartilage metabolism (type II collagen degradation) is enhanced in endurance athletes with intense joint loading. Notably, glucosamine, a chitosan monomer, exhibits a chondroprotective action on osteoarthritis by inhibiting type II collagen degradation. Here, we evaluated the action of glucosamine on cartilage metabolism in soccer and rugby players with intense joint loading. In soccer and rugby players, the urine level of type II collagen degradation maker (CTX-II) was significantly increased compared with non-athlete control, indicating that cartilage metabolism is enhanced in these athletes. In contrast, the urine level of type II collagen synthesis maker (CPII) was almost the same as in non-athletes. These findings suggest that type II collagen degradation is relatively increased compared with type II collagen synthesis in these athletes. Interestingly, the administration of glucosamine-containing diet significantly decreased the CTX-II level but not the CPII level in these athletes. These observations suggest that cartilage metabolism (type II collagen degradation) is increased in endurance athletes (such as soccer and rugby players), and glucosamine demonstrates a chondroprotective action on these athletes by preventing type II collagen degradation but maintaining type II collagen synthesis.
据报道，在承受高强度关节负荷的耐力运动员中，软骨代谢（Ⅱ型胶原降解）增强。值得注意的是，壳聚糖单体氨基葡萄糖对骨关节炎具有软骨保护作用，可抑制Ⅱ型胶原降解。在这里，我们评估了氨基葡萄糖对足球和橄榄球运动员高强度关节负荷下软骨代谢的作用。与非运动员对照组相比，足球和橄榄球运动员的尿液Ⅱ型胶原降解标志物（CTX-II）水平显著升高，表明这些运动员的软骨代谢增强。相比之下，Ⅱ型胶原合成标志物（CPII）的尿液水平与非运动员几乎相同。这些发现表明，与这些运动员的Ⅱ型胶原合成相比，Ⅱ型胶原降解相对增加。有趣的是，含氨基葡萄糖的饮食可显著降低这些运动员的 CTX-II 水平，但不影响 CPII 水平。这些观察结果表明，软骨代谢（Ⅱ型胶原降解）在耐力运动员（如足球和橄榄球运动员）中增加，氨基葡萄糖通过预防Ⅱ型胶原降解而对这些运动员具有软骨保护作用，但维持Ⅱ型胶原合成。
