Department of Medicine for Motor Organs, Juntendo University Graduate School of Medicine, Tokyo 113‑8421, Japan.
Mol Med Rep. 2013 Mar;7(3):742-6. doi: 10.3892/mmr.2013.1289. Epub 2013 Jan 25.
In the present study, the effect of glucosamine administration (1.5 or 3 g/day) on cartilage and bone metabolism was investigated in bicycle racers, using cartilage‑ and bone‑specific biomarkers, including C‑terminal cross‑linked telopeptides of type II collagen (CTX‑II), C‑terminal propeptides of type II procollagen (CPII), N‑terminal telopeptides of bone‑specific type I collagen (NTx) and bone alkaline phosphatase (BAP). The results indicate that CPII (a marker of type II collagen synthesis) was not substantially changed, however, CTX‑II (a marker of type II degradation) was reduced by glucosamine administration, particularly at a dose of 3 g/day. Consistent with these observations, the ratio of CTX‑II/CPII was reduced by glucosamine administration and the effect of glucosamine was dose‑dependent. By contrast, the levels of NTx (a bone resorption marker) and BAP (a bone formation marker) were not altered by glucosamine administration. A previous study by this group reported that glucosamine exerts a chondroprotective action in soccer players by preventing type II collagen degradation but maintaining type II collagen synthesis. Together these observations indicate that glucosamine may exert a chondroprotective action by preventing type II collagen degradation in athletes of various sports, including soccer players and bicycle racers.
在本研究中，我们使用软骨和骨特异性生物标志物，包括Ⅱ型胶原 C 端交联肽（CTX-II）、Ⅱ型前胶原 C 端肽（CPII）、Ⅰ型胶原 N 端肽（NTx）和骨碱性磷酸酶（BAP），研究了氨基葡萄糖（1.5 或 3 g/天）给药对自行车运动员软骨和骨代谢的影响。结果表明，CPII（Ⅱ型胶原合成的标志物）没有明显变化，而 CTX-II（Ⅱ型胶原降解的标志物）在氨基葡萄糖给药时减少，特别是在 3 g/天的剂量时。与这些观察结果一致，CTX-II/CPII 比值在氨基葡萄糖给药时降低，且呈剂量依赖性。相比之下，NTx（骨吸收标志物）和 BAP（骨形成标志物）的水平不受氨基葡萄糖给药的影响。本研究小组的先前研究报告称，氨基葡萄糖通过防止Ⅱ型胶原降解而维持Ⅱ型胶原合成，从而对足球运动员发挥软骨保护作用。这些观察结果表明，氨基葡萄糖可能通过防止各种运动项目运动员（包括足球运动员和自行车运动员）的Ⅱ型胶原降解来发挥软骨保护作用。
