Saague Peter William Kemewele, Moukette Moukette Bruno, Njimou Jacques Romain, Biapa Prosper Cabral Nya, Nzufo Tankeu Francine, Moor Vicky Joseline Ama, Pieme Constant Anatole, Ngogang Jeanne Yonkeu
Laboratory of Biochemistry, Department of Biochemistry and Physiological Sciences, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O. Box 1364, Yaoundé, Cameroon.
Department of Inorganic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
ScientificWorldJournal. 2019 Mar 3;2019:5236851. doi: 10.1155/2019/5236851. eCollection 2019.
Liver diseases are a global health problem. Medicinal plants are being increasingly used to manage a wide variety of diseases including liver disorders. The aim of this study was to investigate the antioxidant properties and hepatoprotective activity of polyphenolic extract from the fruits of .
The extract of was administered at doses of 50 mg/kg and 100 mg/kg for 07 to rats before the induction of hepatotoxicity with of 2 ml/kg of 1:1 (v/v) carbon tetrachloride (CCl) and olive oil through intraperitoneal route. The antioxidant and radical scavenging properties of were conducted by the FRAP method, the phosphomolybdate method, and the inhibition potential of DPPH, ABTS, OH, and NO radicals. The extraction yield of was 19.35%. This extract contains polyphenols (273.48 mg CAE/g DM), flavonoids (5.2549 mg SE/g DM), and flavonols (1.615 mg SE/g DM). This extract showed antioxidant activity, an inhibitor power of various free radicals, and radical scavenging potential dose-dependent. The fifty-percent inhibitory concentration of the extract (IC) for the studied radical varied from 28.16 to 136 g/L. In rats treated with the extract of , in a dose-dependent manner, the levels of hepatotoxicity markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) significantly increased while the enzyme activities of superoxide dismutase (SOD), catalase (CAT), and the level of reduced glutathione (GHS) significantly increased compared to the control group.
The extracts from the fruit of demonstrate antioxidant activity and hepatoprotective effects.
肝脏疾病是一个全球性的健康问题。药用植物越来越多地被用于治疗包括肝脏疾病在内的多种疾病。本研究的目的是调查[植物名称]果实中多酚提取物的抗氧化特性和肝保护活性。
在用2 ml/kg的1:1（v/v）四氯化碳（CCl）和橄榄油通过腹腔注射诱导大鼠肝毒性之前，以50 mg/kg和100 mg/kg的剂量给大鼠施用[植物名称]提取物7天。通过FRAP法、磷钼酸盐法以及对DPPH、ABTS、OH和NO自由基的抑制潜力来测定[植物名称]的抗氧化和自由基清除特性。[植物名称]的提取率为19.35%。该提取物含有多酚（273.48 mg CAE/g DM）、黄酮类化合物（5.2549 mg SE/g DM）和黄酮醇（1.615 mg SE/g DM）。该提取物显示出抗氧化活性、对各种自由基的抑制能力以及剂量依赖性的自由基清除潜力。提取物对所研究自由基的半数抑制浓度（IC）在28.16至136 g/L之间变化。在用[植物名称]提取物处理的大鼠中，与对照组相比，肝毒性标志物如丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和碱性磷酸酶（ALP）的水平呈剂量依赖性显著升高，而超氧化物歧化酶（SOD）、过氧化氢酶（CAT）的酶活性以及还原型谷胱甘肽（GHS）的水平显著升高。
[植物名称]果实提取物具有抗氧化活性和肝保护作用。
