Nasonova S V, Kochina E N, Filimonov R M, Popova I V, Radenska-Lopovok S
Ter Arkh. 1986;58(7):84-9.
Stomach secretory function and gastrin concentration in the blood serum were studied in 45 patients with Sjögren's disease. A sharp decrease in acid- and enzymoforming function of the stomach, disorder of the process of mucus formation and hypergastrinemia were detected in 80% of the patients. The relationship of stomach secretory function, gastrin concentration and the gravity of xerostomia was established. Morphology of the mucosa of the body and antral part of the stomach revealed chronic atrophic gastritis. Massive lymphohistiocytic infiltration of the mucous membrane with focal aggregations of lymphoid elements, atrophy and destruction of the glands were revealed. B-lymphocytes prevailed in the cellular infiltrate. T-lymphocytes were found in a small amount among the infiltrate cells and epithelial cells of the main gastric glands.
对45例干燥综合征患者的胃分泌功能及血清胃泌素浓度进行了研究。80%的患者出现胃酸和胃酶分泌功能急剧下降、黏液形成过程紊乱及高胃泌素血症。确立了胃分泌功能、胃泌素浓度与口干严重程度之间的关系。胃体和胃窦部黏膜形态显示为慢性萎缩性胃炎。可见黏膜大量淋巴细胞和组织细胞浸润，伴有淋巴样细胞灶性聚集、腺体萎缩和破坏。细胞浸润中以B淋巴细胞为主。在浸润细胞及胃主腺上皮细胞中发现少量T淋巴细胞。
