ACS Appl Mater Interfaces. 2019 Apr 24;11(16):14567-14575. doi: 10.1021/acsami.9b00848. Epub 2019 Apr 12.
Biosensor systems for wearable continuous monitoring are desired to be developed into conformal patch platforms. However, developing such patches is very challenging owing to the difficulty of imparting materials and components with both high stretchability and high performance. Herein, we report a fully stretchable microfluidics-integrated glucose sensor patch comprised of an omnidirectionally stretchable nanoporous gold (NPG) electrochemical biosensor and a stretchable passive microfluidic device. A highly electrocatalytic NPG electrode was formed on a stress-absorbing 3D micropatterned polydimethylsiloxane (PDMS) substrate to confer mechanical stretchability, high sensitivity, and durability in non-enzymatic glucose detection. A thin, stretchable, and tough microfluidic device was made by embedding stretchable cotton fabric as a capillary into a thin polyurethane nanofiber-reinforced PDMS channel, enabling collection and passive, accurate delivery of sweat from skin to the electrode surface, with excellent replacement capability. The integrated glucose sensor patch demonstrated excellent ability to continuously and accurately monitor the sweat glucose level.
可穿戴式连续监测的生物传感器系统被期望开发成贴合式贴片平台。然而，由于很难赋予材料和组件兼具高拉伸性和高性能，因此开发此类贴片极具挑战性。在此，我们报告了一种完全可拉伸的微流控集成葡萄糖传感器贴片，它由一个全方位可拉伸的纳米多孔金（NPG）电化学生物传感器和一个可拉伸的无源微流控器件组成。在具有吸能 3D 微图案化的聚二甲基硅氧烷（PDMS）基底上形成了具有高电催化性能的 NPG 电极，从而赋予其在非酶葡萄糖检测中的机械拉伸性、高灵敏度和耐用性。通过将弹性棉织物嵌入到薄的聚氨酯纳米纤维增强 PDMS 通道中，可以制造出一种薄、弹性好且坚韧的微流控器件，从而能够从皮肤收集并被动、准确地将汗液输送到电极表面，具有优异的替换能力。集成的葡萄糖传感器贴片表现出了连续、准确监测汗液葡萄糖水平的卓越能力。
