Sondhi Palak, Lingden Dhanbir, Bhattarai Jay K, Demchenko Alexei V, Stine Keith J
Department of Chemistry and Biochemistry, University of Missouri-Saint Louis, Saint Louis, MO 63121, USA.
Mallinckrodt Pharmaceuticals Company, Saint Louis, MO 63042, USA.
Metals (Basel). 2023 Jan;13(1). doi: 10.3390/met13010078. Epub 2022 Dec 28.
Nanoporous gold (np-Au) has promising applications in therapeutic delivery. The promises arise from its high surface area-to-volume ratio, ease of tuning shape and size, ability to be modified by organic molecules including drugs, and biocompatibility. Furthermore, np-Au nanostructures can generate the photothermal effect. This effect can be used either for controlled release of drugs of therapeutic importance or for destroying cancer cells by heating locally. Despite the enormous potential, the research on the therapeutical use of the np-Au is still in its early stage. In this review, we discuss the current progress and future directions of np-Au for therapeutic applications.
纳米多孔金（np-Au）在治疗性给药方面具有广阔的应用前景。这些前景源于其高的表面积与体积比、易于调节的形状和尺寸、能够被包括药物在内的有机分子修饰以及生物相容性。此外，np-Au纳米结构能够产生光热效应。这种效应可用于重要治疗药物的控释，或通过局部加热来破坏癌细胞。尽管具有巨大潜力，但关于np-Au治疗用途的研究仍处于早期阶段。在这篇综述中，我们讨论了np-Au在治疗应用方面的当前进展和未来方向。
