Department of Oral Biology, University of Pittsburgh School of Dental Medicine, Pittsburgh, Pennsylvania, USA,
Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia.
Caries Res. 2019;53(4):482-488. doi: 10.1159/000496542. Epub 2019 Apr 3.
Molar-incisor hypomineralization (MIH) is a condition that is defined based on its peculiar clinical presentation. Original reports on the etiology of the condition and possible risk factors were inconclusive, and we refuted the original suggestion that MIH is an idiopathic condition and suggested that MIH has complex inheritance and is due to the interaction of more than one gene and the environment. Our group was the first to suggest MIH has a genetic component that involves genetic variation in genes expressed during dental enamel formation. Later we expanded this work to include genes related to the immune response. In this report, we provide a rationale to explain the variation seen in the clinical presentation of MIH, which can affect just one molar out of the four or just a portion of a particular molar.
磨牙-切牙釉质发育不全（MIH）是一种根据其特殊临床表现定义的疾病。最初关于该疾病病因和可能危险因素的报告尚无定论，我们驳斥了 MIH 是一种特发性疾病的最初建议，并提出 MIH 具有复杂的遗传性，是由一个以上基因与环境相互作用引起的。我们小组是第一个提出 MIH 具有遗传成分的，这涉及到牙釉质形成过程中表达的基因的遗传变异。后来，我们将这项工作扩展到包括与免疫反应相关的基因。在本报告中，我们提供了一个解释 MIH 临床表现变化的原理，这种变化可能只影响四颗磨牙中的一颗，或者只影响特定磨牙的一部分。
