发酵支原体对人淋巴细胞的促有丝分裂活性。
Mitogenicity of Mycoplasma fermentans for human lymphocytes.
作者信息
Nilsson E
出版信息
Infect Immun. 1978 Jul;21(1):48-54. doi: 10.1128/iai.21.1.48-54.1978.
Abstract
The in vitro stimulation response of human lymphocytes to Mycoplasma fermentans was examined. M. fermentans stimulated DNA synthesis in blood lymphocytes from all of 20 healthy subjects examined. Only one of these subjects had complement-fixing antibodies to M. fermentans. Lymphocytes from 21 of 22 adenoids and from 1 spleen were also stimulated to DNA synthesis by M. fermentans. The organism induced DNA synthesis in both B and T lymphocytes from adenoids and spleen and preferentially in T lymphocytes from blood. M. fermentans was shown to activate adenoid lymphocytes to non-amtogem-specific antibody secretion demonstrable by a hemolytic plaque assay. It is concluded that M. fermentans can have a mitogenic effect on both B and T lymphocytes.
摘要
检测了人淋巴细胞对发酵支原体的体外刺激反应。发酵支原体刺激了所检测的20名健康受试者血液淋巴细胞中的DNA合成。这些受试者中只有一人有针对发酵支原体的补体结合抗体。22个腺样体中的21个以及1个脾脏中的淋巴细胞也受到发酵支原体刺激而发生DNA合成。该微生物在腺样体和脾脏的B淋巴细胞和T淋巴细胞中均诱导DNA合成，且优先在血液的T淋巴细胞中诱导合成。发酵支原体可激活腺样体淋巴细胞分泌非抗原特异性抗体，这可通过溶血空斑试验证实。结论是，发酵支原体可对B淋巴细胞和T淋巴细胞产生促有丝分裂作用。
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