支原体促细胞分裂素对B淋巴细胞的激活作用。
Activation of B lymphocytes by mycoplasma mitogen(s).
作者信息
Naot Y, Ginsburg H
出版信息
Immunology. 1978 Apr;34(4):715-20.
Abstract
Various strains of the murine mycoplasma M. neurolyticum have been shown to induce extensive blast transformation of mouse lymphocytes, comparable in strength to mitogenicity exerted by these mycoplasma species on rat lymphocytes. The data summarized in this report demonstrate that this mitogenic effect is non-specific. Lymphoid cells from mycoplasma free, germ-free mice were activated to the same extent as those lymphocytes obtained from conventionally bred animals. Lymph node cell suspensions obtained from athymic nude mice were strongly activated by M. neurolyticum mitogen. Furthermore, mouse thymocytes and mouse T-cell enriched populations, were not stimulated by these mitogens. It was thus suggested that M. neurolyticum activates mouse B lymphocytes.
摘要
已证明鼠源溶神经支原体的各种菌株可诱导小鼠淋巴细胞广泛的母细胞转化，其强度与这些支原体对大鼠淋巴细胞的促有丝分裂作用相当。本报告总结的数据表明，这种促有丝分裂作用是非特异性的。来自无支原体、无菌小鼠的淋巴细胞与从常规饲养动物获得的淋巴细胞被激活的程度相同。从无胸腺裸鼠获得的淋巴结细胞悬液被溶神经支原体促有丝分裂原强烈激活。此外，小鼠胸腺细胞和富含小鼠T细胞的群体未受到这些促有丝分裂原的刺激。因此表明溶神经支原体激活小鼠B淋巴细胞。
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