From the Departments of Nutrition (M.C., A.A., K.L.M.) and Epidemiology (A.A.), Harvard T.H. Chan School of Public Health, Boston, MA; Department of Global Public Health and Primary Care (M.C.), University of Bergen, Norway; and Partners Multiple Sclerosis Center (T.C.) and Channing Division of Network Medicine, Department of Medicine (A.A.), Brigham and Women's Hospital, Boston, MA.
Neurology. 2019 Apr 30;92(18):e2127-e2135. doi: 10.1212/WNL.0000000000006800. Epub 2019 Apr 3.
To investigate the association between mineral intake (potassium, magnesium, calcium, phosphorus, iron, zinc, manganese, copper) and multiple sclerosis (MS) risk.
In a prospective cohort study, we assessed dietary and supplemental mineral intake by a validated food frequency questionnaire administered every 4 years to 80,920 nurses in the Nurses' Health Study (1984-2002) and 94,511 in the Nurses' Health Study II (1991-2007). There were 479 new MS cases during follow-up. We estimated hazard ratios and 95% confidence intervals for the association of energy-adjusted mineral intake with MS risk using Cox regression, adjusting for age, residence latitude at age 15, ancestry, body mass index at age 18, supplemental vitamin D, smoking, and total energy intake.
We did not find any association between the minerals and MS risk, either for baseline or cumulative intake during follow-up. The associations were null comparing women with highest to those with lowest intakes in quintiles or deciles and there was no significant trend for higher intakes ( across baseline quintiles: potassium 0.35, magnesium 0.13, calcium 0.22, phosphorus 0.97, iron 0.85, zinc 0.67, manganese 0.48, copper 0.59).
Our findings suggest that mineral intake is not an important determinant of MS risk.
研究矿物质摄入（钾、镁、钙、磷、铁、锌、锰、铜）与多发性硬化症（MS）风险之间的关系。
在一项前瞻性队列研究中，我们通过经过验证的食物频率问卷评估了护士健康研究（1984-2002 年）中 80920 名护士和护士健康研究 II（1991-2007 年）中 94511 名护士的膳食和补充矿物质摄入情况。在随访期间，有 479 例新的 MS 病例。我们使用 Cox 回归估计了能量调整后的矿物质摄入与 MS 风险之间的风险比和 95%置信区间，调整了年龄、15 岁时的居住地纬度、祖籍、18 岁时的体重指数、补充维生素 D、吸烟和总能量摄入。
我们没有发现任何矿物质与 MS 风险之间的关联，无论是基线还是随访期间的累积摄入。与五分之一或十分之一最低摄入量的女性相比，最高摄入量的女性之间的相关性为零，并且没有明显的摄入趋势（ 从基线五分位数来看：钾 0.35、镁 0.13、钙 0.22、磷 0.97、铁 0.85、锌 0.67、锰 0.48、铜 0.59）。
我们的研究结果表明，矿物质摄入不是 MS 风险的重要决定因素。
