US Department of Health and Human Services/Assistant Secretary for Preparedness and Response/Biomedical Advanced Research and Development Authority, Washington, DC.
Department of Pediatrics, University of Maryland School of Medicine, Baltimore.
Clin Infect Dis. 2020 Feb 14;70(5):773-779. doi: 10.1093/cid/ciz264.
Recent reports have described the contribution of adult respiratory syncytial virus (RSV) infections to the use of advanced healthcare resources and death.
Data regarding patients aged ≥18 years admitted to any of Maryland's 50 acute-care hospitals were evaluated over 12 consecutive years (2001-2013). We examined RSV and influenza (flu) surveillance data from the US National Respiratory and Enteric Virus Surveillance System and the Centers for Disease Control and Prevention and used this information to define RSV and flu outbreak periods in the Maryland area. Outbreak periods consisted of consecutive individual weeks during which at least 10% of RSV and/or flu diagnostic tests were positive. We examined relationships of RSV and flu outbreaks to occurrence of 4 advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation, and death) due to medically attended acute respiratory illness (MAARI).
Occurrences of all 4 MAARI-related hospital advanced medical outcomes were consistently greater for all adult ages during RSV, flu, and combined RSV-flu outbreak periods compared to nonoutbreak periods and tended to be greatest in adults aged ≥65 years during combined RSV-flu outbreak periods. Rate ratios for all 4 MAARI-related advanced medical outcomes ranged from 1.04 to 1.38 during the RSV, flu, or combined RSV-flu outbreaks compared to the nonoutbreak periods, with all 95% lower confidence limits >1.
Both RSV and flu outbreaks were associated with surges in MAARI-related advanced medical outcomes (hospitalization, intensive care unit admission, intubated mechanical ventilation, and death) for adults of all ages.
最近的报告描述了成人呼吸道合胞病毒（RSV）感染对使用先进医疗资源和死亡的贡献。
对马里兰州 50 家急性护理医院中年龄≥18 岁的患者的数据进行了 12 年的连续评估（2001-2013 年）。我们检查了美国国家呼吸道和肠道病毒监测系统和疾病控制与预防中心的 RSV 和流感（流感）监测数据，并利用这些信息来确定马里兰州地区的 RSV 和流感爆发期。爆发期由连续的个别星期组成，在此期间，至少有 10%的 RSV 和/或流感诊断检测呈阳性。我们研究了 RSV 和流感爆发与因医疗相关的急性呼吸道疾病（MAARI）而发生的 4 种高级医疗结局（住院、重症监护病房入院、插管机械通气和死亡）之间的关系。
与非爆发期相比，所有年龄组的成人在 RSV、流感和 RSV-流感联合爆发期间，所有 4 种与 MAARI 相关的医院高级医疗结局的发生率始终更高，并且在 RSV-流感联合爆发期间，年龄≥65 岁的成年人的发生率最高。与非爆发期相比，在 RSV、流感或 RSV-流感联合爆发期间，所有 4 种与 MAARI 相关的高级医疗结局的发生率比值范围为 1.04 至 1.38，所有 95%置信区间下限均>1。
RSV 和流感爆发都与所有年龄段成年人因 MAARI 相关的高级医疗结局（住院、重症监护病房入院、插管机械通气和死亡）的激增有关。
