Regional Health Authority of Umbria, Perugia, Italy.
Neurology Clinic, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.
Neurol Sci. 2019 Aug;40(8):1709-1712. doi: 10.1007/s10072-019-03872-w. Epub 2019 Apr 3.
Parkinson's disease is known to pose a significant burden on society in industrialized countries. However, few studies have been conducted in Italy using administrative healthcare databases for epidemiological purposes. We wanted to estimate the incidence and prevalence rates of Parkinson's disease in the Italian region of Umbria by means of linkage between several sources of administrative healthcare data: hospitalization episodes, exemptions from medical charges, drug prescriptions from general practitioners and physicians working in the public sector. Using a pre-defined algorithm, we estimated incident and prevalent cases of Parkinson's disease for the year 2016. The regional incidence rate, adjusted with Italian standard population data, was 0.40 new cases/1000 person-years (0.41 in females, 0.39 in males). We estimated that 5550 subjects were affected by Parkinson's disease, leading to an age-adjusted prevalence rate of 5.42/1000 inhabitants. Prevalence and incidence increased with age and male gender. However, due to the longer life expectancy of females, the absolute number of prevalent cases was greater among females. The heterogeneity of spatial distribution of disease was high. A considerable proportion of prevalent cases was hospitalized in 2016. The most recurrent reasons for hospitalization episodes were disorders related to the nervous system, respiratory system, cardiovascular system, and musculoskeletal and connective tissue apparatus. The study findings support the feasibility of future epidemiological studies of Parkinson's disease with administrative data as well as the need for an integrative care pathway for the patients with Parkinson's disease.
帕金森病在工业化国家对社会造成了重大负担。然而，意大利很少有研究使用行政医疗保健数据库进行流行病学研究。我们希望通过将多个行政医疗保健数据源（住院病例、医疗费用豁免、全科医生和公立部门医生开具的药物处方）进行链接，来估计意大利翁布里亚地区帕金森病的发病率和患病率。使用预定义的算法，我们估计了 2016 年帕金森病的新发和现患病例。经意大利标准人口数据调整后的区域发病率为 0.40 例/1000 人年（女性为 0.41，男性为 0.39）。我们估计有 5550 名患者患有帕金森病，导致年龄调整后的患病率为 5.42/1000 居民。患病率和发病率随年龄和性别而增加。然而，由于女性的预期寿命更长，因此女性的现患病例绝对数量更多。疾病空间分布的异质性很高。相当一部分现患病例在 2016 年住院。住院病例最常见的原因是与神经系统、呼吸系统、心血管系统以及肌肉骨骼和结缔组织器官有关的疾病。研究结果支持使用行政数据进行未来帕金森病的流行病学研究，并需要为帕金森病患者建立综合护理途径。
