3-氧化吲哚与吲哚及芳烃的氧化偶联反应。
Oxidative Coupling of 3-Oxindoles with Indoles and Arenes.
作者信息
Kang Houng, Jemison Adriana L, Nigro Erin, Kozlowski Marisa C
机构信息
Department of Chemistry, Roy and Diana Vagelos Laboratories, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.
出版信息
ChemSusChem. 2019 Jul 5;12(13):3144-3151. doi: 10.1002/cssc.201900438. Epub 2019 May 27.
Abstract
A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96 %) without prefunctionalization.
摘要
描述了一种高效的方法，用于将2-取代的3-氧化吲哚与芳香族化合物进行氧化偶联，以形成具有广泛适用范围的2,2-二取代吲哚啉-3-酮。这项工作在温和条件下使用氧气作为终端氧化剂和贱金属催化剂，而不是有毒/贵金属试剂和高分子量氧化剂。无需预官能化即可以中等至优异的产率（高达96%）生成季结构。
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