Lange L, Fritzsch T, Hilmann J, Kubowicz G, Mützel W
Arzneimittelforschung. 1986 Jul;36(7):1037-40.
Right-ventricular contrast provided by the new standardized sonographic contrast agent SH U 454, which consists of pure galactose microparticles, with 300 mg microparticles/ml and by 5 other currently employed ultrasonic contrast media was examined by 2 D echocardiography in 10 anesthetized female beagle dogs (6.8-12.7 kg) following i.v. administration. With a 5-min interval between injections each animal was given 3 injections of 2 ml of each formulation in random order using an injection speed of approximately 2 ml/s. The echocardiographic investigation was recorded on videotape and the contrast assessed blind using a visual score system (rating 0-5) by two investigators working independently and also by a videodensitometer. Only SH U 454 caused an intense, homogeneous and reproducible opacification of the right heart chambers. By comparison with other formulations for right-heart echocontrast, SH U 454 was significantly superior (p less than 0.05) in every parameter assessed.
由新型标准化超声造影剂SH U 454（由纯半乳糖微粒组成，微粒浓度为300毫克/毫升）以及其他5种目前使用的超声造影剂所提供的右心室造影，在10只麻醉后的雌性比格犬（体重6.8 - 12.7千克）静脉注射后，通过二维超声心动图进行了检查。每次注射间隔5分钟，每只动物以大约2毫升/秒的注射速度，随机顺序接受每种制剂2毫升的3次注射。超声心动图检查记录在录像带上，由两名独立工作的研究人员使用视觉评分系统（评分0 - 5）以及视频密度计对造影进行盲法评估。只有SH U 454能使右心腔产生强烈、均匀且可重复的显影。与其他用于右心超声造影的制剂相比，SH U 454在评估的每个参数上均显著更优（p小于0.05）。
