合成纳米颗粒受体对糖鞘脂的识别与保护
Recognition and protection of glycosphingolipids by synthetic nanoparticle receptors.
作者信息
Gunasekara Roshan W, Zhao Yan
机构信息
Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA.
出版信息
Chem Commun (Camb). 2019 Apr 18;55(33):4773-4776. doi: 10.1039/c9cc01694e.
Abstract
Nanoparticle receptors were synthesized through micellar imprinting to bind glycosphingolipids with 20-140 μM binding affinities, meanwhile distinguishing glycan composition, the number of acyl chains, and hydroxylation of acyl chains in the lipids. The strong binding enabled the receptors to protect their target glycolipids dispersed in lipid membranes from enzymatic degradation.
摘要
通过胶束印迹法合成了纳米颗粒受体，以结合具有20 - 140μM结合亲和力的糖鞘脂，同时区分脂质中聚糖组成、酰基链数量和酰基链的羟基化情况。这种强结合能力使受体能够保护分散在脂质膜中的目标糖脂免受酶促降解。
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