骨髓基质（间质）干细胞的衰老和谱系分配变化。
Aging and lineage allocation changes of bone marrow skeletal (stromal) stem cells.
机构信息
The Molecular Endocrinology & Stem Cell Research Unit (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern Denmark, Odense, Denmark; Clinical Research Center, Copenhagen University Hospital, Hvidovre, Denmark.
The Molecular Endocrinology & Stem Cell Research Unit (KMEB), Department of Endocrinology, Odense University Hospital & University of Southern Denmark, Odense, Denmark; Department of Cellular and Molecular Medicine, The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Panum Institute, University of Copenhagen, Copenhagen, Denmark.
出版信息
Bone. 2019 Jun;123:265-273. doi: 10.1016/j.bone.2019.03.041. Epub 2019 Apr 1.
Aging is associated with decreased bone mass and accumulation of bone marrow adipocytes. Both bone forming osteoblastic cells and bone marrow adipocytes are derived from a stem cell population within the bone marrow stroma called bone marrow stromal (skeletal or mesenchymal) stem cells (BMSC). In the present review, we provide an overview, based on the current literature, regarding the physiological aging processes that cause changes in BMSC lineage allocation, enhancement of adipocyte and defective osteoblast differentiation, leading to gradual exhaustion of stem cell regenerative potential and defects in bone tissue homeostasis and metabolism. We discuss strategies to preserve the "youthful" state of BMSC, to reduce bone marrow age-associated adiposity, and to counteract the overall negative effects of aging on bone tissues with the aim of decreasing bone fragility and risk of fractures.
衰老是与骨量减少和骨髓脂肪细胞积累相关的。成骨细胞和骨髓脂肪细胞均来源于骨髓基质中的一个干细胞群体，称为骨髓基质（骨骼或间充质）干细胞（BMSC）。在本综述中，我们根据当前的文献，提供了一个概述，内容涉及导致 BMSC 谱系分配发生变化、增强脂肪细胞和缺陷成骨细胞分化的生理衰老过程，这些变化导致干细胞再生潜能逐渐耗尽，以及骨组织稳态和代谢的缺陷。我们讨论了保持 BMSC 的“年轻”状态、减少与骨髓年龄相关的脂肪堆积以及对抗衰老对骨骼组织的整体负面影响的策略，目的是降低骨折的脆弱性和风险。
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