Huang Ying, Chen Xi, You Ze Shan, Gu Fang, Li Li, Wang Dongyu, Liu Jun, Li Yinguang, He Shanyang
Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Pediatrics, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
J Matern Fetal Neonatal Med. 2022 Jun;35(11):2031-2035. doi: 10.1080/14767058.2020.1774543. Epub 2020 Jun 29.
To explore the potential clinical value of platelet parameters in early pregnancy in predicting gestational diabetes mellitus (GDM).
A total of 1188 singleton pregnant women were included in the regular antenatal examination and delivered in the First Affiliated Hospital of Sun Yat-Sen University from January 2016 to December 2018, who had no pre-pregnancy diabetes, no factors leading to elevated blood glucose level, no medical complications and no other obstetrical complications. Blood routine examination was performed at the 11-13 gestational weeks. All pregnant women underwent 75 g OGTT directly at the 24-28th gestational weeks. And they were divided into GDM group ( = 192) and non-GDM group ( = 996). Binomial Logistic regression analysis and receiver operating characteristic (ROC) curve were used to evaluate the ability of first-trimester platelet parameters to predict GDM, that is the sensitivity and specificity of platelet parameters at the optimal critical value.
There were significant differences in platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT) between the GDM group and the normal group (＜.05). After adjusting for the related factors such as maternal age, parity and pregestational body mass index (BMI), the MPV and PCT were correlated with the incidence of GDM (＜.05). The area under the curve (AUC) of MPV was 0.577; 95% confidence interval (CI) 0.533-0.621 and that of PCT was 0.628. 95%CI 0.582-0.674. PLT and PDW were not correlated with GDM.
MPV and PCT in early pregnancy are potential indicators in predicting gestational diabetes mellitus.
探讨孕早期血小板参数预测妊娠期糖尿病（GDM）的潜在临床价值。
选取2016年1月至2018年12月在中山大学附属第一医院定期产检并分娩的1188名单胎孕妇，这些孕妇孕前无糖尿病，无导致血糖升高的因素，无内科并发症及其他产科并发症。于孕11 - 13周进行血常规检查。所有孕妇在孕24 - 28周直接行75g口服葡萄糖耐量试验（OGTT），并分为GDM组（n = 192）和非GDM组（n = 996）。采用二项Logistic回归分析和受试者工作特征（ROC）曲线评估孕早期血小板参数预测GDM的能力，即血小板参数在最佳临界值时的敏感性和特异性。
GDM组与正常组在血小板计数（PLT）、血小板分布宽度（PDW）、平均血小板体积（MPV）和血小板压积（PCT）方面存在显著差异（P＜0.05）。校正孕妇年龄、孕周、孕前体质指数（BMI）等相关因素后，MPV和PCT与GDM的发生相关（P＜0.05）。MPV的曲线下面积（AUC）为0.577，95%置信区间（CI）为0.533 - 0.621；PCT的AUC为0.628，95%CI为0.582 - 0.674。PLT和PDW与GDM无关。
孕早期MPV和PCT是预测妊娠期糖尿病的潜在指标。
