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肝脏与腹腔疾病

The Liver and Celiac Disease.

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA.

Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA.

出版信息

Clin Liver Dis. 2019 May;23(2):167-176. doi: 10.1016/j.cld.2018.12.001. Epub 2019 Mar 1.

DOI:10.1016/j.cld.2018.12.001
PMID:30947869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6588186/
Abstract

Celiac disease is a multisystem disorder. Celiac hepatitis characterized by gluten-responsive mild elevation of transaminases is the more common liver manifestation of celiac disease. Celiac disease may also be associated or coexist with other chronic liver disorders. Shared genetic risk and increased intestinal permeability have been suggested to be the most relevant events in the pathogenesis of liver injury in celiac disease. The aim of this article is to review the full spectrum of liver disorders in patients with celiac disease.

摘要

乳糜泻是一种多系统疾病。乳糜泻肝炎的特征是麸质反应性转氨酶轻度升高,是乳糜泻更常见的肝脏表现。乳糜泻也可能与其他慢性肝脏疾病有关或并存。遗传易感性和增加的肠通透性被认为是乳糜泻患者肝损伤发病机制中最相关的事件。本文旨在综述乳糜泻患者的所有肝脏疾病谱。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4171/6588186/94fa523f1ebe/nihms-1522988-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4171/6588186/8f48d9036931/nihms-1522988-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4171/6588186/94fa523f1ebe/nihms-1522988-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4171/6588186/8f48d9036931/nihms-1522988-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4171/6588186/94fa523f1ebe/nihms-1522988-f0002.jpg

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The Liver and Celiac Disease.肝脏与腹腔疾病
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2
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Liver Int. 2025 Aug;45(8):e70206. doi: 10.1111/liv.70206.
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Celiac Crisis in the Postpartum: A Life-Threatening Cause of Diarrhea and Malnutrition.产后乳糜泻危象:腹泻与营养不良的致命病因
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Coeliac disease and chronic liver disease: a double-face issue.乳糜泻与慢性肝病:一个双面问题。

本文引用的文献

1
Celiac Disease and Liver Disorders: From Putative Pathogenesis to Clinical Implications.乳糜泻与肝脏疾病:从推测的发病机制到临床意义。
Nutrients. 2018 Jul 12;10(7):892. doi: 10.3390/nu10070892.
2
Increased risk of nonalcoholic fatty liver disease in patients with coeliac disease on a gluten-free diet: beyond traditional metabolic factors. gluten-free 饮食的乳糜泻患者非酒精性脂肪肝疾病风险增加:超越传统代谢因素。
Aliment Pharmacol Ther. 2018 Sep;48(5):538-546. doi: 10.1111/apt.14910. Epub 2018 Jul 8.
3
Mortality in coeliac disease: a population-based cohort study from a single centre in Southern Derbyshire, UK.
Lancet Reg Health Eur. 2025 Jan 24;50:101216. doi: 10.1016/j.lanepe.2025.101216. eCollection 2025 Mar.
4
Celiac Disease, Gluten-Free Diet and Metabolic Dysfunction-Associated Steatotic Liver Disease.乳糜泻、无麸质饮食与代谢相关脂肪性肝病。
Nutrients. 2024 Jun 25;16(13):2008. doi: 10.3390/nu16132008.
5
Severe Hepatitis Complicating Olmesartan Enteropathy: A Case Report.严重肝炎并发奥美沙坦肠病:一例报告
Case Rep Gastroenterol. 2024 Apr 25;18(1):238-243. doi: 10.1159/000538552. eCollection 2024 Jan-Dec.
6
Fatty liver and celiac disease: Why worry?脂肪肝与乳糜泻:为何担忧?
World J Hepatol. 2023 May 27;15(5):666-674. doi: 10.4254/wjh.v15.i5.666.
7
Celiac disease screening in patients with cryptogenic cirrhosis.对隐源性肝硬化患者进行乳糜泻筛查。
World J Gastroenterol. 2023 Jan 14;29(2):410-412. doi: 10.3748/wjg.v29.i2.410.
8
Bi-directional Relationship Between Celiac Disease and Liver Chemistries: A Systematic Review and Meta-Analysis.乳糜泻与肝脏生化指标之间的双向关系:一项系统评价和荟萃分析
Dig Dis Sci. 2023 Apr;68(4):1369-1380. doi: 10.1007/s10620-022-07663-w. Epub 2022 Aug 24.
9
Review article: Follow-up of coeliac disease.综述文章: 腹腔疾病的随访。
Aliment Pharmacol Ther. 2022 Jul;56 Suppl 1(Suppl 1):S49-S63. doi: 10.1111/apt.16847.
10
Microbiome and metabolome profiles of high screen time in a cohort of healthy college students.健康大学生队列中高屏幕时间的微生物组和代谢组特征。
Sci Rep. 2022 Mar 2;12(1):3452. doi: 10.1038/s41598-022-07381-3.
乳糜泻的死亡率:一项基于英国德比郡南部一个单一中心的人群队列研究。
BMJ Open Gastroenterol. 2018 Apr 17;5(1):e000201. doi: 10.1136/bmjgast-2018-000201. eCollection 2018.
4
Clinicopathological and immunological characteristics and outcome of concomitant coeliac disease and non-alcoholic fatty liver disease in adults: a large prospective longitudinal study.成人乳糜泻与非酒精性脂肪性肝病并存的临床病理、免疫学特征及预后:一项大型前瞻性纵向研究
BMJ Open Gastroenterol. 2018 Jan 29;5(1):e000150. doi: 10.1136/bmjgast-2017-000150. eCollection 2018.
5
Coeliac disease and the liver: spectrum of liver histology, serology and treatment response at a tertiary referral centre.乳糜泻与肝脏:三级转诊中心的肝脏组织学、血清学及治疗反应谱
J Clin Pathol. 2018 May;71(5):412-419. doi: 10.1136/jclinpath-2017-204647. Epub 2017 Sep 29.
6
ACG Clinical Guideline: Evaluation of Abnormal Liver Chemistries.美国胃肠病学会临床指南:异常肝功能检查结果的评估
Am J Gastroenterol. 2017 Jan;112(1):18-35. doi: 10.1038/ajg.2016.517. Epub 2016 Dec 20.
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Hypertransaminasemia in Newly Diagnosed Pediatric Patients With Celiac Disease.新诊断的乳糜泻儿科患者中的高转氨酶血症
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Dig Liver Dis. 2016 Sep;48(9):1023-9. doi: 10.1016/j.dld.2016.05.022. Epub 2016 Jun 2.
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Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US population.美国人群中乳糜泻患者肝功能检查异常的患病率及无麸质饮食的影响。
Am J Gastroenterol. 2015 Aug;110(8):1216-22. doi: 10.1038/ajg.2015.192. Epub 2015 Jul 7.