Karaca Can A, Coker Ahmet
1Department of General Surgery, Faculty of Medicine, Izmir University of Economics, İzmir, Turkey.
2Izmir Ekonomi Universitesi Sakarya Caddesi, No:156, 35330, Balcova, Izmir Turkey.
Indian J Surg Oncol. 2019 Mar;10(1):50-54. doi: 10.1007/s13193-018-0824-9. Epub 2018 Oct 26.
Lymph node involvement in pancreatic adenocancer is one of the strongest predictors of prognosis. However, the extent of lymph node dissection is still a matter of debate and number of dissected nodes varies widely among patients. In order to homogenize this diverse group of patients and more accurately predict their prognosis, we aimed to analyze the effect of metastatic lymph node ratio as an independent prognostic factor. We retrospectively analyzed medical recordings of 326 patients with pancreatic cancer who were treated in a tertiary medical oncology center over a 10-year period. Both in univariate and multivariate analyses, metastatic lymph node ratio proved to be a strong predictor of prognosis which was unaffected from heterogeneity of our patient population and can be used to facilitate predict prognosis of patients who underwent lymph node dissection to various extents and with future studies it can emerge as a successful tool for creating prognostic subgroups of the disease.
胰腺癌中的淋巴结受累是预后的最强预测指标之一。然而，淋巴结清扫的范围仍是一个有争议的问题，且不同患者清扫的淋巴结数量差异很大。为了使这一多样化的患者群体同质化并更准确地预测他们的预后，我们旨在分析转移淋巴结比率作为独立预后因素的作用。我们回顾性分析了在一家三级肿瘤中心接受治疗的326例胰腺癌患者10年期间的医疗记录。在单变量和多变量分析中，转移淋巴结比率均被证明是预后的有力预测指标，不受我们患者群体异质性的影响，可用于促进预测不同程度接受淋巴结清扫的患者的预后，并且在未来的研究中它可能成为创建该疾病预后亚组的成功工具。
