Huang Guan-Cheng, Tsai Yi-Zhe, Lee Chia-Jung, Chang Heng-Yu, Wang Ching-Chiung
Division of Hemato-Oncology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung City 802, Taiwan.
Program of Health-Business Administration, School of Nursing, Fooyin University, Kaohsiung City 831, Taiwan.
Evid Based Complement Alternat Med. 2019 Mar 5;2019:4761651. doi: 10.1155/2019/4761651. eCollection 2019.
Si-Wu Tang (SWT), a traditional Chinese formula, is commonly used for treating female diseases, such as relief of menstrual discomfort and climacteric syndrome. The aim of this study was to explore the synergistic effects between each herb in SWT on menstrual disorder patterns. Estradiol regulation and antioxidative effects were indicators that ameliorated menstrual disorder patterns and the total polyphenol and polysaccharide contents were quality markers. According to relationships of bioactivity and phytochemical contents, we discuss the effects of each herb in SWT. In a testosterone-treated MCF-7 cell model, and catalpol significantly increased the estradiol content and aromatase upregulation in cell culture. We suggest that catalpol is an aromatase promoter in SWT, and . is a major actor. In terms of the antioxidant activity, pentagalloylglucose, gallic acid, and ferulic acid had stronger antioxidative effects than other compounds. We suggest that the antioxidative ability depends on polyphenols, and is a major contributor. Based on the prescribing principle of traditional Chinese medicine (TCM) theory, we suggest that . in SWT act as an aromatase promoter in the role of sovereign for ameliorating menstrual disorder patterns. As . has the strongest antioxidant effects and can prevent ROS damage ovarian; therefore, . could help . work as a minister for menstrual disorder patterns and and are a herbal pair in SWT.
四物汤（SWT）是一种传统中药配方，常用于治疗妇科疾病，如缓解月经不适和更年期综合征。本研究的目的是探讨四物汤中各味药材对月经紊乱模式的协同作用。雌二醇调节和抗氧化作用是改善月经紊乱模式的指标，总多酚和多糖含量是质量标志物。根据生物活性与植物化学物质含量的关系，我们讨论了四物汤中各味药材的作用。在睾酮处理的MCF-7细胞模型中，梓醇显著增加了细胞培养物中的雌二醇含量并上调了芳香化酶。我们认为梓醇是四物汤中的芳香化酶促进剂，并且……是主要作用成分。在抗氧化活性方面，五倍子酰葡萄糖、没食子酸和阿魏酸比其他化合物具有更强的抗氧化作用。我们认为抗氧化能力取决于多酚，并且……是主要贡献者。基于中医理论的组方原则，我们认为四物汤中的……作为芳香化酶促进剂在改善月经紊乱模式中起君药作用。由于……具有最强的抗氧化作用，可以防止活性氧对卵巢的损伤；因此，……可以帮助……在月经紊乱模式中起臣药作用，并且……和……是四物汤中的药对。
