阿魏酸在病理生理条件下改善作用的新见解。
New insights into the ameliorative effects of ferulic acid in pathophysiological conditions.
作者信息
Ghosh Sumit, Basak Priyanka, Dutta Sayanta, Chowdhury Sayantani, Sil Parames C
机构信息
Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata 700054, India.
出版信息
Food Chem Toxicol. 2017 May;103:41-55. doi: 10.1016/j.fct.2017.02.028. Epub 2017 Feb 23.
Ferulic acid, a natural phytochemical has gained importance as a potential therapeutic agent by virtue of its easy commercial availability, low cost and minimal side-effects. It is a derivative of curcumin and possesses the necessary pharmacokinetic properties to be retained in the general circulation for several hours. The therapeutic effects of ferulic acid are mediated through its antioxidant and anti-inflammatory properties. It exhibits different biological activities such as anti-inflammatory, anti-apoptotic, anti-carcinogenic, anti-diabetic, hepatoprotective, cardioprotective, neuroprotective actions, etc. The current review addresses its therapeutic effects under different pathophysiological conditions (eg. cancer, cardiomyopathy, skin disorders, brain disorders, viral infections, diabetes etc.).
阿魏酸是一种天然植物化学物质，因其易于商业获取、成本低且副作用小，作为一种潜在的治疗剂而受到重视。它是姜黄素的衍生物，具有必要的药代动力学特性，可在体循环中保留数小时。阿魏酸的治疗作用是通过其抗氧化和抗炎特性介导的。它表现出不同的生物活性，如抗炎、抗凋亡、抗癌、抗糖尿病、保肝、心脏保护、神经保护作用等。本综述阐述了其在不同病理生理条件下（如癌症、心肌病、皮肤疾病、脑部疾病、病毒感染、糖尿病等）的治疗作用。
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