CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
PLoS Biol. 2019 Apr 5;17(4):e3000213. doi: 10.1371/journal.pbio.3000213. eCollection 2019 Apr.
Adenosine modulation is considered both a paracrine signal coordinating different cells in a tissue and a stress signal. Both functions are ensured by 4 types of adenosine receptors (ARs), which have been studied individually. Mice with knockout of all ARs (quad-AR-KO) now allow enquiring the overall function of the adenosine modulation system. The observed "normal" physiology of quad-AR-KO mice indicates that ARs do not regulate homeostasis and are likely recruited to selectively control allostasis.
腺苷调节被认为既是一种旁分泌信号，协调组织中不同细胞的活动，也是一种应激信号。这两种功能都是由 4 种类型的腺苷受体 (AR) 来保证的，这些受体已经被分别研究过了。现在，通过敲除所有 AR（四 AR 敲除）的小鼠，我们可以研究腺苷调节系统的整体功能。观察到的四 AR 敲除小鼠的“正常”生理学表明，AR 不调节体内平衡，而是可能被招募来选择性地控制体内平衡。
