Karolinska Institutet, Department of Biosciences and Nutrition & Center for Innovative Medicine, NEO, 141 83 Huddinge, Sweden.
Karolinska Institutet, Department of Biosciences and Nutrition & Center for Innovative Medicine, NEO, 141 83 Huddinge, Sweden.
Cell Stem Cell. 2019 Apr 4;24(4):501-502. doi: 10.1016/j.stem.2019.03.014.
Tissue-resident immune cells with potent sensing and effector functions are well-placed to fundamentally aid tissue homeostasis via crosstalk with stem cells. In this issue of Cell Stem Cell, Wang et al. (2019) identify a dermis-resident TREM2+ macrophage subpopulation that promotes hair follicle stem cell quiescence via cytokine-mediated JAK-STAT signaling.
组织驻留免疫细胞具有强大的感应和效应功能，通过与干细胞的相互作用，非常适合从根本上帮助组织稳态。在本期《Cell Stem Cell》杂志上，Wang 等人（2019 年）鉴定出一种真皮驻留的 TREM2+巨噬细胞亚群，该亚群通过细胞因子介导的 JAK-STAT 信号通路促进毛囊干细胞静止。
