Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel.
Multiple Sclerosis Center, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; Sagol School of Neuroscience, Tel-Aviv University, Tel Aviv, Israel.
Mult Scler Relat Disord. 2019 Jun;31:82-86. doi: 10.1016/j.msard.2019.03.025. Epub 2019 Apr 1.
There is limited information as to the effects of aerobic exercise on the immune system in people with multiple sclerosis (PwMS). One of the unresolved questions is which training intensity level is optimal for PwMS.
The purpose of this study is to compare the effects of moderate intensity with the effects of vigorous intensity on cytokine levels in women with mild MS.
The study included 15 women with MS and a control of 10 healthy women. The initial session determined the value of the maximum oxygen consumption and was carried out on an instrumented treadmill with a portable system for monitoring gases. During the second session, the participant walked on the treadmill for 15-minutes at a moderate capacity level (∼50% VO peak). Blood samples were taken at baseline, immediately after exercise and two hours later. IL-4, IL-6, IL-10, IL-17A, TNF-α and IFN-ɣ cytokines were tested. The third session was identical to the second except for a vigorous training intensity session (∼80% VO peak).
IL-6 increased after moderate exercise for both the MS (p = 0.02) and control group (p = 0.02). IL-10 decreased during the vigorous session only in the MS group (p = 0.02). No other differences were seen over time in either group for all other cytokine measurements.
With the exception of IL-10, women with mild MS have similar inflammatory reactions to moderate and high intensity exercise as do healthy women.
关于有氧运动对多发性硬化症患者（PwMS）免疫系统的影响，信息有限。尚未解决的问题之一是，哪种训练强度水平对 PwMS 最理想。
本研究的目的是比较中等强度与剧烈强度对轻度 MS 女性细胞因子水平的影响。
该研究包括 15 名 MS 女性和 10 名健康女性作为对照组。初始阶段确定了最大耗氧量的值，并在带有便携式气体监测系统的带仪器跑步机上进行。在第二次会议期间，参与者在跑步机上以中等速度（约 50% VO 峰值）行走 15 分钟。在基线、运动后立即和两小时后采集血样。测试了 IL-4、IL-6、IL-10、IL-17A、TNF-α 和 IFN-γ 细胞因子。第三次会议与第二次会议相同，只是剧烈训练强度会议（约 80% VO 峰值）。
中强度运动后，MS（p=0.02）和对照组（p=0.02）的 IL-6 均增加。仅在 MS 组中，剧烈运动期间 IL-10 下降（p=0.02）。在任何其他时间点，两组的其他细胞因子测量均未显示出差异。
除了 IL-10 之外，轻度 MS 女性对中等强度和高强度运动的炎症反应与健康女性相似。
