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整合素及其在免疫细胞黏附中的作用。

Integrins and Their Role in Immune Cell Adhesion.

机构信息

Kennedy Institute of Rheumatology, NDORMS, The University of Oxford, Oxfordshire OX3 7FY, UK.

出版信息

Cell. 2019 Apr 18;177(3):499-501. doi: 10.1016/j.cell.2019.03.038. Epub 2019 Apr 2.

DOI:10.1016/j.cell.2019.03.038
PMID:30952447
Abstract

One of the 2019 Canada Gairdner International Awards recognizes Timothy Springer's discovery of the first immune system adhesion molecules involved in lymphocyte homing and the translation of those discoveries into therapeutics for autoimmune disease and cancer.

摘要

2019 年加拿大盖尔德纳国际奖之一表彰了蒂莫西·斯普林格发现的第一个参与淋巴细胞归巢的免疫系统黏附分子,并将这些发现转化为治疗自身免疫性疾病和癌症的疗法。

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Integrins and Their Role in Immune Cell Adhesion.整合素及其在免疫细胞黏附中的作用。
Cell. 2019 Apr 18;177(3):499-501. doi: 10.1016/j.cell.2019.03.038. Epub 2019 Apr 2.
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Characterisation of adhesion receptors mediating lymphocyte adhesion to bronchial endothelium provides evidence for a distinct lung homing pathway.介导淋巴细胞与支气管内皮细胞黏附的黏附受体的特征分析为一条独特的肺归巢途径提供了证据。
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Immature mast cells exhibit rolling and adhesion to endothelial cells and subsequent diapedesis triggered by E- and P-selectin, VCAM-1 and PECAM-1.未成熟的肥大细胞表现出与内皮细胞的滚动和黏附,并随后通过 E- 选择素和 P- 选择素、VCAM-1 和 PECAM-1 触发出芽。
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Integrins, ICAMs, and selectins: role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites.整合素、细胞间黏附分子和选择素:黏附分子在中性粒细胞募集至炎症部位中的作用及调控
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Triggering of motile behavior in T lymphocytes via cross-linking of alpha 4 beta 1 and alpha L beta 2.通过α4β1和αLβ2交联触发T淋巴细胞的运动行为。
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Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering.整合素α4β7/α4βP在淋巴细胞与纤连蛋白和血管细胞黏附分子-1的黏附以及同型细胞聚集中的作用。
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Adhesion molecules in cell interactions.细胞相互作用中的黏附分子。
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