Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas (CSIC) and Universidad Miguel Hernandez (UMH), Campus de Sant Joan, Apartado 18, 03550 Sant Joan, Alicante, Spain
Dis Model Mech. 2019 Apr 1;12(4):dmm039032. doi: 10.1242/dmm.039032.
When Mary Stark first described the presence of tumours in the fruit fly in 1918, would she ever have imagined that flies would become an invaluable organism for modelling and understanding oncogenesis? And if so, would she have expected it to take 100 years for this model to be fully accredited? This Special Article summarises the efforts and achievements of Drosophilists to establish the fly as a valid model in cancer research through different scientific periods.
当玛丽·斯塔克(Mary Stark)于 1918 年首次描述果蝇中肿瘤的存在时,她是否曾想象过苍蝇会成为一种用于模拟和理解致癌作用的无价生物体? 如果是这样,她是否期望这个模型需要 100 年才能得到充分认可? 本文总结了果蝇学家通过不同的科学时期努力将果蝇确立为癌症研究中有效模型的工作和成就。