Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Brief Bioinform. 2020 May 21;21(3):863-875. doi: 10.1093/bib/bbz032.
The nervous system is one of the most complex biological systems, and nervous system disease (NSD) is a major cause of disability and mortality. Extensive evidence indicates that numerous dysregulated microRNAs (miRNAs) are involved in a broad spectrum of NSDs. A comprehensive review of miRNA-mediated regulatory will facilitate our understanding of miRNA dysregulation mechanisms in NSDs. In this work, we summarized currently available databases on miRNAs and NSDs, star NSD miRNAs, NSD spectrum width, miRNA spectrum width and the distribution of miRNAs in NSD sub-categories by reviewing approximately 1000 studies. In addition, we characterized miRNA-miRNA and NSD-NSD interactions from a network perspective based on miRNA-NSD benchmarking data sets. Furthermore, we summarized the regulatory principles of miRNAs in NSDs, including miRNA synergistic regulation in NSDs, miRNA modules and NSD modules. We also discussed computational challenges for identifying novel miRNAs in NSDs. Elucidating the roles of miRNAs in NSDs from a network perspective would not only improve our understanding of the precise mechanism underlying these complex diseases, but also provide novel insight into the development, diagnosis and treatment of NSDs.
神经系统是最复杂的生物系统之一，神经系统疾病（NSD）是导致残疾和死亡的主要原因。大量证据表明，许多失调的 microRNA（miRNA）参与了广泛的 NSD。对 miRNA 介导的调控进行全面综述将有助于我们理解 NSD 中 miRNA 失调的机制。在这项工作中，我们通过回顾大约 1000 项研究，总结了目前可用的 miRNA 和 NSD 数据库、星形 NSD miRNA、NSD 谱宽、miRNA 谱宽以及 miRNA 在 NSD 子类别中的分布。此外，我们还基于 miRNA-NSD 基准数据集从网络角度刻画了 miRNA-miRNA 和 NSD-NSD 相互作用。此外，我们总结了 miRNAs 在 NSD 中的调控原则，包括 NSD 中 miRNA 的协同调控、miRNA 模块和 NSD 模块。我们还讨论了在 NSD 中识别新 miRNAs 的计算挑战。从网络角度阐明 miRNAs 在 NSD 中的作用不仅可以提高我们对这些复杂疾病精确机制的理解，而且还为 NSD 的发展、诊断和治疗提供新的思路。
