Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, Tübingen, Germany.
Peptides. 2019 Apr;114:38-43. doi: 10.1016/j.peptides.2019.04.002. Epub 2019 Apr 3.
The recently discovered peptide phoenixin was initially implicated in reproduction as a regulator of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release from the pituitary. Subsequently, various functions of phoenixin have been demonstrated including mediation of itching sensation, stimulation of vasopressin secretion, stimulation of white adipogenesis and hypothalamic nutrient sensing. Subsequently, additional actions of phoenixin have been described, namely effects on behavior. A systematic search of four data bases was performed and original articles selected accordingly. The present systematic review will present the current knowledge on the effects of phoenixin on different behaviors such as anxiety and food intake as well as cognition. Lastly, gaps in knowledge will be mentioned to stimulate further research.
最近发现的肽凤凰素最初被认为是一种调节促性腺激素释放激素（GnRH）刺激垂体分泌黄体生成素（LH）的物质，与生殖有关。随后，人们发现了凤凰素的各种功能，包括介导瘙痒感、刺激血管加压素分泌、刺激白色脂肪生成和下丘脑营养感应。随后，又描述了凤凰素的其他作用，即对行为的影响。对四个数据库进行了系统搜索，并根据原始文章进行了选择。本系统综述将介绍凤凰素对不同行为（如焦虑和食物摄入以及认知）的影响的最新知识。最后，将提到知识空白以激发进一步的研究。
