Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 12203 Berlin, Germany.
Department of Psychosomatic Medicine and Psychotherapy, Medical University Hospital Tübingen, 72076 Tübingen, Germany.
Int J Mol Sci. 2018 Jun 11;19(6):1726. doi: 10.3390/ijms19061726.
Phoenixin is a recently discovered brain peptide initially thought to be restricted to reproductive functions. The subsequent identification of phoenixin’s expression in peripheral tissues was accompanied by the description of several other actions of this hormone, such as effects on behavior, sensory perception, memory retention, the cardiovascular system as well as food intake, pointing towards a pleiotropic role of this peptide. The present review will discuss the present knowledge on phoenixin and the signaling involved as well as highlight gaps in knowledge to stimulate further research.
凤凰素是一种最近发现的脑肽，最初被认为仅限于生殖功能。随后在周围组织中发现了凤凰素的表达，并描述了这种激素的其他几种作用，如对行为、感觉感知、记忆保留、心血管系统以及食物摄入的影响，表明这种肽具有多效性作用。本文综述了凤凰素及其涉及的信号转导的现有知识，并强调了知识空白，以激发进一步的研究。
