Synthesizing T1 weighted MPRAGE image from multi echo GRE images via deep neural network.

For quantitative neuroimaging studies using multi-echo gradient echo (mGRE) images, additional T-weighted magnetization prepared rapid gradient echo (MPRAGE) images are often acquired to supplement the insufficient morphometric information of mGRE for tissue segmentation which require lengthened scan time and additional processing such as image registration. This study investigated the feasibility of generating synthetic MPRAGE images from mGRE images using a deep convolutional neural network. Tissue segmentation results derived from the synthetic MPRAGE showed good agreement with those from actual MPRAGE (DSC = 0.882 ± 0.017). There was no statistically significant difference between the mean susceptibility values obtained with the regions of interest from synthetic and actual MPRAGEs and high correlation between the two measurements.