Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Korea.
Korean J Radiol. 2022 Jul;23(7):742-751. doi: 10.3348/kjr.2022.0003. Epub 2022 May 27.
To assess focal mineral deposition in the globus pallidus (GP) by CT and quantitative susceptibility mapping (QSM) of MRI scans and evaluate its clinical significance, particularly cerebrovascular degeneration.
This study included 105 patients (66.1 ± 13.7 years; 40 male and 65 female) who underwent both CT and MRI with available QSM data between January 2017 and December 2019. The presence of focal mineral deposition in the GP on QSM (GP) and CT (GP) was assessed visually using a three-point scale. Cerebrovascular risk factors and small vessel disease (SVD) imaging markers were also assessed. The clinical and radiological findings were compared between the different grades of GP and GP. The relationship between GP grades and cerebrovascular risk factors and SVD imaging markers was assessed using univariable and multivariable linear regression analyses.
GP and GP were significantly associated ( < 0.001) but were not identical. Higher GP and GP grades showed smaller gray matter ( = 0.030 and = 0.025, respectively) and white matter ( = 0.013 and = 0.019, respectively) volumes, as well as larger GP volumes ( < 0.001 for both). Among SVD markers, white matter hyperintensity was significantly associated with GP ( = 0.006) and brain atrophy was significantly associated with GP ( = 0.032) in at univariable analysis. In multivariable analysis, the normalized volume of the GP was independently positively associated with GP ( < 0.001) and GP ( = 0.002), while the normalized volume of the GM was independently negatively associated with GP ( = 0.040) and GP ( = 0.035).
Focal mineral deposition in the GP on CT and QSM might be a potential imaging marker of cerebral vascular degeneration. Both were associated with increased GP volume.
通过 CT 扫描和磁共振成像（MRI）的定量磁化率映射（QSM）评估苍白球（GP）的局灶性矿物质沉积，并评估其临床意义，特别是脑血管变性。
本研究纳入了 105 名患者（66.1±13.7 岁；男 40 例，女 65 例），这些患者在 2017 年 1 月至 2019 年 12 月期间进行了 CT 和 MRI 检查，并且都有 QSM 数据。使用三点评分法评估 QSM 上 GP（GP）和 CT 上 GP（GP）局灶性矿物质沉积的存在情况。还评估了脑血管危险因素和小血管疾病（SVD）成像标志物。比较了不同等级 GP 和 GP 的临床和影像学表现。使用单变量和多变量线性回归分析评估了 GP 等级与脑血管危险因素和 SVD 成像标志物之间的关系。
GP 和 GP 具有显著相关性（<0.001），但并不完全相同。较高的 GP 和 GP 等级显示出较小的灰质（=0.030 和=0.025）和白质体积（=0.013 和=0.019），以及更大的 GP 体积（两者均<0.001）。在 SVD 标志物中，白质高信号在单变量分析中与 GP（=0.006）显著相关，脑萎缩与 GP（=0.032）显著相关。在多变量分析中，GP 的标准化体积与 GP（<0.001）和 GP（=0.002）独立正相关，而 GM 的标准化体积与 GP（=0.040）和 GP（=0.035）独立负相关。
CT 和 QSM 上苍白球的局灶性矿物质沉积可能是脑血管退行性变的潜在影像学标志物。两者均与 GP 体积增加相关。
