Computational Developmental Biology Group, Department of Biology, Utrecht University, Utrecht, the Netherlands.
Computational Developmental Biology Group, Department of Biology, Utrecht University, Utrecht, the Netherlands.
Mol Plant. 2019 Jun 3;12(6):784-803. doi: 10.1016/j.molp.2019.03.015. Epub 2019 Apr 3.
The root system is a major determinant of a plant's access to water and nutrients. The architecture of the root system to a large extent depends on the repeated formation of new lateral roots. In this review, we discuss lateral root development from a systems biology perspective. We focus on studies combining experiments with computational modeling that have advanced our understanding of how the auxin-centered regulatory modules involved in different stages of lateral root development exert their specific functions. Moreover, we discuss how these regulatory networks may enable robust transitions from one developmental stage to the next, a subject that thus far has received limited attention. In addition, we analyze how environmental factors impinge on these modules, and the different manners in which these environmental signals are being integrated to enable coordinated developmental decision making. Finally, we provide some suggestions for extending current models of lateral root development to incorporate multiple processes and stages. Only through more comprehensive models we can fully elucidate the cooperative effects of multiple processes on later root formation, and how one stage drives the transition to the next.
根系是植物获取水分和养分的主要决定因素。根系的结构在很大程度上取决于新侧根的反复形成。在这篇综述中，我们从系统生物学的角度讨论侧根的发育。我们专注于将实验与计算建模相结合的研究，这些研究增进了我们对参与侧根发育不同阶段的以生长素为中心的调控模块如何发挥其特定功能的理解。此外，我们还讨论了这些调控网络如何能够实现从一个发育阶段到下一个发育阶段的稳健转变，这是一个迄今为止受到关注较少的主题。此外，我们分析了环境因素如何影响这些模块，以及不同的方式来整合这些环境信号，以实现协调的发育决策。最后，我们提出了一些建议，以扩展当前的侧根发育模型，将多个过程和阶段纳入其中。只有通过更全面的模型，我们才能充分阐明多个过程对侧根形成的协同作用，以及一个阶段如何驱动向另一个阶段的转变。
