MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, PR China.
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, PR China.
Biomaterials. 2019 Jul;207:39-48. doi: 10.1016/j.biomaterials.2019.03.042. Epub 2019 Mar 30.
A tumor-related stimuli-activatable and biodegradable nanoplatform for tumor-selective imaging and effective photodynamic therapy (PDT) towards precision medicine is highly desirable but still greatly challenging. Here, we developed a novel HO-activatable and biodegradable nanomedicine (BSA-MBPB) by encapsulation of a single newly synthesized pro-photosensitizer (MBPB) with its photoactivity completely annihilated within bovine serum albumin (BSA) to achieve imaging-guided tumor-targeted effective PDT. BSA-MBPB can be decomposed and activated by HO to not only produce the clinical photosensitizer methylene blue to recover its fluorescent, photoacoustic and photosensitizing properties for dual-modal imaging and cytotoxic singlet oxygen (O) generation, but also to simultaneously produce a GSH-depleting adjuvant quinone methide to boost the O yield, thus strengthening the efficacy of PDT. BSA-MBPB allows for highly efficient and accurate PDT without major side effects, offering potential as the next-generation nanomedicine towards clinical practice of precise PDT.
一种肿瘤相关刺激激活和可生物降解的纳米平台，用于肿瘤选择性成像和针对精准医学的有效光动力疗法（PDT），这是非常理想的，但仍然极具挑战性。在这里，我们通过将单一新型合成的前光敏剂（MBPB）封装在牛血清白蛋白（BSA）内来开发一种新型的 HO 激活和可生物降解的纳米药物（BSA-MBPB），其光活性在 BSA 内完全被消除，以实现成像引导的肿瘤靶向有效 PDT。BSA-MBPB 可被 HO 分解和激活，不仅产生临床光敏剂亚甲蓝以恢复其荧光、光声和光敏特性，用于双模成像和细胞毒性单线态氧（O）的产生，而且还同时产生耗竭 GSH 的辅助醌甲，以提高 O 的产量，从而增强 PDT 的疗效。BSA-MBPB 允许高效和准确的 PDT，而没有大的副作用，为下一代纳米药物提供了向精准 PDT 的临床实践迈进的潜力。
