Department of Biomedical Sciences, College of Health Sciences, Qatar University, Doha, Qatar.
Department of Nutrition, College of Health Sciences, Qatar University, Doha, Qatar.
Diabetes Res Clin Pract. 2019 May;151:198-208. doi: 10.1016/j.diabres.2019.03.037. Epub 2019 Apr 4.
T2DM reach epidemic levels in the Arab countries. In this study, we aimed to perform a systematic review and meta-analysis to underline the susceptibility genetic profile of Arab patients with T2DM that result from SNPs.
We searched four literature databases (PubMed, Scopus, Science Direct and Web of Science) through January 2019. We included all SNPs in candidate genes with an OR > 1 that were associated with T2DM among Arab patients with T2DM. Statistical programs such as software Review Manager (Version 5.02) and STATA (Version 15.1) were used. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with a random effects model or a fixed effect model depending on the heterogeneity among studies. I statistics and Egger's tests were performed to assess heterogeneity and publication bias.
Out of 2245 studies, 47 were used for meta-analysis. We captured 31,307 cases and 26,464 controls in which we collected 71 SNPs in 32 genes. A pooled meta-analysis demonstrated 24-69% increase in T2DM risk. Among the 57 SNPs (in 32 genes) that were not included in the meta-analysis, the OR for diabetes ranged from 1.02 to 5.10, with a median of 1.38 (interquartile range 1.33-2.09). Ten studies examined the association between the TCF7L2 polymorphism rs7903146 and T2DM, leading to an aggregated OR of 1.34 (95%CI 1.27-1.41).
The genetic profile that confer susceptibility to T2DM in Arab patients is diverse. This study may serve as a platform for designing a gene panel for testing the susceptibility to T2DM.
2 型糖尿病在阿拉伯国家达到流行水平。在这项研究中，我们旨在进行系统评价和荟萃分析，以强调阿拉伯 2 型糖尿病患者中 SNP 导致的易感性遗传特征。
我们通过 2019 年 1 月前的四个文献数据库（PubMed、Scopus、Science Direct 和 Web of Science）进行了搜索。我们纳入了所有候选基因中的 SNP，这些 SNP 与阿拉伯 2 型糖尿病患者的 2 型糖尿病相关，其 OR>1。我们使用了统计程序，如 Review Manager（版本 5.02）和 STATA（版本 15.1）。使用随机效应模型或固定效应模型根据研究之间的异质性计算汇总优势比（OR）和 95%置信区间（CI）。我们使用 I 统计量和 Egger 检验评估异质性和发表偏倚。
在 2245 项研究中，有 47 项用于荟萃分析。我们共纳入了 31307 例病例和 26464 例对照，其中我们共收集了 32 个基因中的 71 个 SNP。汇总分析显示，2 型糖尿病风险增加 24%-69%。在未纳入荟萃分析的 57 个 SNP（32 个基因）中，糖尿病的 OR 范围为 1.02 至 5.10，中位数为 1.38（四分位距 1.33-2.09）。有 10 项研究检验了 TCF7L2 多态性 rs7903146 与 2 型糖尿病之间的关系，导致汇总 OR 为 1.34（95%CI 1.27-1.41）。
赋予阿拉伯 2 型糖尿病患者易感性的遗传特征是多样化的。本研究可为设计用于检测 2 型糖尿病易感性的基因面板提供依据。
