Hamidi Yeganeh, Saki Sahar, Afraz Elham Sadat, Pashapour Sanaz
Department of Biology, Faculty of Basic Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran.
Department of Biology, Faculty of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran.
J Diabetes Metab Disord. 2022 Jul 12;21(2):1895-1901. doi: 10.1007/s40200-022-01086-0. eCollection 2022 Dec.
There is extensive research on the association between polymorphisms in the adiponectin gene (ADIPOQ) and type 2 diabetes (T2D). The present meta-analytic study explored the association between ADIPOQ rs2241766 polymorphisms and T2D.
Articles were collected by searching Google Scholar, Scopus, and PubMed electronic databases until 2021. They were searched using a systematic search of original and sensitive English keywords and their equivalent keywords based on the keywords "type 2 diabetes", "ADIPOQ", and "rs2241766". The article selection criteria were based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram.
The results revealed that there was no bias in this study. Some studies, such as Joshaghani et al. (odds ratio [OR] = 2.18), Hussain et al. (OR = 2.12), Momin (OR = 4.45), and Amal et al. (OR = 1.84), showed an increasing effect of ADIPOQ rs266729 polymorphism on T2D with 95% CI (P ˂ 0.01), while some have shown no significant association between them.
The results of this meta-analytic study showed the relationship between ADIPOQ and rs2241766. Also, it was found that Rs2241766 polymorphism and allele increase the risk, and rs2241766 increases the risk of developing T2D (OR = 1.29).
关于脂联素基因（ADIPOQ）多态性与2型糖尿病（T2D）之间的关联已有大量研究。本荟萃分析研究探讨了ADIPOQ rs2241766多态性与T2D之间的关联。
通过检索谷歌学术、Scopus和PubMed电子数据库收集截至2021年的文章。使用基于“2型糖尿病”、“ADIPOQ”和“rs2241766”的原始和敏感英文关键词及其等效关键词进行系统检索。文章选择标准基于PRISMA（系统评价和荟萃分析的首选报告项目）流程图。
结果显示本研究无偏倚。一些研究，如乔沙哈尼等人（优势比[OR]=2.18）、侯赛因等人（OR=2.12）、莫敏（OR=4.45）和阿迈勒等人（OR=1.84），显示ADIPOQ rs266729多态性对T2D有增加作用，95%置信区间（P＜0.01），而一些研究则表明它们之间无显著关联。
本荟萃分析研究结果显示了ADIPOQ与rs2241766之间的关系。此外，发现Rs2241766多态性和等位基因会增加风险，rs2241766会增加患T2D的风险（OR=1.29）。
