脂联素基因（ADIPOQ）rs2241766多态性与2型糖尿病相关性的Meta分析。

A Meta-analysis of ADIPOQ rs2241766 polymorphism association with type 2 diabetes.

作者信息

Hamidi Yeganeh, Saki Sahar, Afraz Elham Sadat, Pashapour Sanaz

机构信息

Department of Biology, Faculty of Basic Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran.

Department of Biology, Faculty of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran.

出版信息

J Diabetes Metab Disord. 2022 Jul 12;21(2):1895-1901. doi: 10.1007/s40200-022-01086-0. eCollection 2022 Dec.

DOI:10.1007/s40200-022-01086-0

PMID:36404807

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9672214/

Abstract

OBJECTIVE

There is extensive research on the association between polymorphisms in the adiponectin gene (ADIPOQ) and type 2 diabetes (T2D). The present meta-analytic study explored the association between ADIPOQ rs2241766 polymorphisms and T2D.

METOLDS

Articles were collected by searching Google Scholar, Scopus, and PubMed electronic databases until 2021. They were searched using a systematic search of original and sensitive English keywords and their equivalent keywords based on the keywords "type 2 diabetes", "ADIPOQ", and "rs2241766". The article selection criteria were based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram.

RESULTS

The results revealed that there was no bias in this study. Some studies, such as Joshaghani et al. (odds ratio [OR] = 2.18), Hussain et al. (OR = 2.12), Momin (OR = 4.45), and Amal et al. (OR = 1.84), showed an increasing effect of ADIPOQ rs266729 polymorphism on T2D with 95% CI (P ˂ 0.01), while some have shown no significant association between them.

CONCLUSION

The results of this meta-analytic study showed the relationship between ADIPOQ and rs2241766. Also, it was found that Rs2241766 polymorphism and allele increase the risk, and rs2241766 increases the risk of developing T2D (OR = 1.29).

摘要