皱褶假丝酵母（粗糙假丝酵母）对抗真菌药物和精油化合物的敏感性分析。
Susceptibility profile of Candida rugosa (Diutina rugosa) against antifungals and compounds of essential oils.
机构信息
Laboratório de Pesquisas Micológicas, Departamento de Microbiologia e Parasitologia, Campus UFSM, Prédio 20, Sala 4139, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.
Programa de Pós graduação em Ciências Veterinárias, Universidade Federal do Mato Grosso, 97105-900 Cuiabá, Brazil.
出版信息
J Mycol Med. 2019 Jun;29(2):154-157. doi: 10.1016/j.mycmed.2019.03.002. Epub 2019 Apr 5.
Candida rugosa (recently reclassified Diutina rugosa) is an emerging pathogen affecting humans and animals. Candida resistance to existing drugs is an important factor to be monitored, as well as the need of researching alternatives to conventional antifungals. Here, we evaluated the in vitro effects of some antifungals and major components of essential oils by the broth microdilution method (CLSI M27-A3) against fifteen C. rugosa strains from animals isolated and molecular identificated. The results showed MIC of: 0.125μg/mL to ketoconazole and voriconazole, 0.25μg/mL to micafungin, 0.5μg/mL to anidulafungin, 1μg/mL to caspofungin, 2μg/mL to amphotericin B, itraconazole and flucytosin, 8μg/mL to fluconazole, 16μg/mL to nystatin and >128μg/mL to terbinafine. The compounds carvacrol (MIC 320μg/mL), thimol (MIC 320μg/mL) and cinnamaldehyde (MIC 160μg/mL) demonstrated antifungal activity against the samples tested.
皱褶假丝酵母（最近重新分类为粗糙假丝酵母）是一种影响人类和动物的新兴病原体。 念珠菌对现有药物的耐药性是一个需要监测的重要因素，同时也需要研究替代传统抗真菌药物的方法。 在这里，我们通过肉汤微量稀释法（CLSI M27-A3）评估了一些抗真菌药物和精油主要成分对从动物中分离并分子鉴定的十五株皱褶假丝酵母菌株的体外作用。 结果显示：酮康唑和伏立康唑的 MIC 为 0.125μg/mL，米卡芬净为 0.25μg/mL，阿尼达弗南净为 0.5μg/mL，卡泊芬净为 1μg/mL，两性霉素 B、伊曲康唑和氟胞嘧啶的 MIC 为 2μg/mL，氟康唑为 8μg/mL，制霉菌素为 16μg/mL，特比萘芬为 >128μg/mL。 化合物香芹酚（MIC 320μg/mL）、麝香草酚（MIC 320μg/mL）和肉桂醛（MIC 160μg/mL）对测试的样品显示出抗真菌活性。
Zotero 插件