Department of Health Promotion Medicine, Niigata University Graduate School of Medical and Dental Sciences.
Division of Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences.
J Epidemiol. 2020 Apr 5;30(4):170-176. doi: 10.2188/jea.JE20180220. Epub 2019 Apr 6.
Evidence for primary prevention of chronic kidney disease (CKD) is insufficient. The population-based prospective Uonuma CKD cohort study aims to explore associations of lifestyle and other risk factors with CKD. We report here the study design and baseline profiles.
All 67,322 residents aged ≥40 years in Minamiuonuma City, Uonuma City, and Yuzawa Town, Niigata Prefecture, Japan and 11,406 participants who attended local health-check examinations were targeted for baseline questionnaire and biochemical sampling, respectively. Information was gathered from 43,217 (64.2%) questionnaires and 8,052 (70.6%) biochemical samples; 6,945 participants consented to both questionnaire and biochemical sampling at baseline, conducted between fiscal years 2012 and 2015. Participants provided information regarding sociodemographic, lifestyle, and self-reported outcomes. Urine albumin-to-creatinine ratio (ACR) and estimated glomerular filtration rate (eGFR) were measured. The primary outcome is CKD based on self-report and biochemical/clinical diagnosis.
Mean age of questionnaire respondents was 63.3 (standard deviation [SD], 12.5) years for men and 64.3 (SD, 13.3) years for women. Among participants who submitted urine samples, median ACR was 10.0 (interquartile range [IQR], 5.0-24.0) mg/g for men and 13.0 (IQR, 7.7-27.0) mg/g for women, and median eGFR was 73.6 mL/min/1.73 m (IQR, 63.5-84.5) for men and 73.5 mL/min/1.73 m (IQR, 64.4-83.5) for women. ACR 30 mg/g or more was found in 1,741 participants (21.7%) and eGFR <60 mL/min/1.73 m in 1,361 participants (16.9%).
The Uonuma CKD cohort study was established to investigate the impact of lifestyle on CKD development and to provide data for preventing the onset and progression of CKD.
目前预防慢性肾脏病（CKD）的证据还不够充分。本项基于人群的前向乌野川 CKD 队列研究旨在探索生活方式和其他危险因素与 CKD 的关联。本研究报告了其设计和基线特征。
本研究以日本新潟县鱼沼市、南鱼沼市和十日町市的 67322 名年龄≥40 岁的居民以及参加当地健康检查的 11406 名参与者为研究对象，分别进行基线问卷调查和生化采样。共收到 43217 份（64.2%）问卷和 8052 份（70.6%）生化样本；2012-2015 年期间，有 11406 名参与者参加了当地健康检查，其中 43217 名（64.2%）完成了问卷调查，8052 名（70.6%）提供了生化样本。6945 名参与者同时完成了问卷调查和生化采样，作为基线数据。参与者提供了社会人口统计学、生活方式和自我报告结果等方面的信息。测量了尿白蛋白与肌酐的比值（ACR）和估算肾小球滤过率（eGFR）。基于自我报告和生化/临床诊断的 CKD 是主要结局。
问卷调查应答者的平均年龄为男性 63.3（标准差[SD]，12.5）岁，女性 64.3（SD，13.3）岁。在提交尿液样本的参与者中，男性的 ACR 中位数为 10.0（四分位距[IQR]，5.0-24.0）mg/g，女性为 13.0（IQR，7.7-27.0）mg/g，男性的 eGFR 中位数为 73.6 mL/min/1.73 m（IQR，63.5-84.5），女性为 73.5 mL/min/1.73 m（IQR，64.4-83.5）。1741 名参与者（21.7%）的 ACR 大于等于 30mg/g，1361 名参与者（16.9%）的 eGFR 小于 60mL/min/1.73 m。
本研究建立了乌野川 CKD 队列研究，旨在探讨生活方式对 CKD 发生发展的影响，并为预防 CKD 的发生和进展提供数据。
