• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

src感染的骨髓培养物中造血功能紊乱和多能干细胞克隆的产生是癌基因的间接或短暂效应。

Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene.

作者信息

Wyke J A, Stoker A W, Searle S, Spooncer E, Simmons P, Dexter T M

出版信息

Mol Cell Biol. 1986 Mar;6(3):959-63. doi: 10.1128/mcb.6.3.959-963.1986.

DOI:10.1128/mcb.6.3.959-963.1986
PMID:3095630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367598/
Abstract

Multipotential stem cell lines, derived specifically from long-term bone marrow cultures infected with a recombinant retrovirus carrying v-src, lack v-src. Stable consequences thus result from transient actions or indirect effects of v-src on other cells, with the latter possibility being favored by its mosaic expression in marrow cultures.

摘要

多能干细胞系是从感染携带v-src的重组逆转录病毒的长期骨髓培养物中特异性衍生而来的，这些细胞系不含v-src。因此，稳定的结果源于v-src对其他细胞的瞬时作用或间接影响，后一种可能性因其在骨髓培养物中的镶嵌表达而更受青睐。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bbd/367598/ac380fe06d97/molcellb00087-0225-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bbd/367598/1db129f5b0c2/molcellb00087-0224-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bbd/367598/c479c935f373/molcellb00087-0225-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bbd/367598/ac380fe06d97/molcellb00087-0225-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bbd/367598/1db129f5b0c2/molcellb00087-0224-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bbd/367598/c479c935f373/molcellb00087-0225-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bbd/367598/ac380fe06d97/molcellb00087-0225-b.jpg

相似文献

1
Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene.src感染的骨髓培养物中造血功能紊乱和多能干细胞克隆的产生是癌基因的间接或短暂效应。
Mol Cell Biol. 1986 Mar;6(3):959-63. doi: 10.1128/mcb.6.3.959-963.1986.
2
Expression of v-src induces a myeloproliferative disease in bone-marrow-reconstituted mice.v-src的表达在骨髓重建小鼠中引发骨髓增殖性疾病。
Genes Dev. 1989 Jun;3(6):827-37. doi: 10.1101/gad.3.6.827.
3
Retroviral src gene expression in continuous marrow culture increases the self-renewal capacity of multilineage hematopoietic stem cells.逆转录病毒src基因在连续骨髓培养中的表达可提高多谱系造血干细胞的自我更新能力。
Leukemia. 1989 Mar;3(3):206-26.
4
Comparison of three recombinant murine leukemia viruses carrying the v-src oncogene of avian sarcoma virus: differences in in vitro transformation and in vivo pathogenicity.
Mol Carcinog. 1988;1(1):57-66. doi: 10.1002/mc.2940010112.
5
v-src mutations outside the carboxyl-coding region are not sufficient to fully activate transformation by pp60c-src in NIH 3T3 cells.羧基编码区域以外的v-src突变不足以在NIH 3T3细胞中通过pp60c-src完全激活转化。
Mol Cell Biol. 1988 Feb;8(2):704-12. doi: 10.1128/mcb.8.2.704-712.1988.
6
Over-expression of c-src or v-src in bone marrow stromal cells stimulates hematopoiesis in long-term bone marrow culture.骨髓基质细胞中c-src或v-src的过表达可刺激长期骨髓培养中的造血作用。
Blood. 1992 Dec 15;80(12):3079-89.
7
A recombinant murine retrovirus expressing v-rel is cytopathic.
Virology. 1988 Jul;165(1):182-90. doi: 10.1016/0042-6822(88)90671-x.
8
Correlation of V-src gene amplification with the tumorigenic phenotype in a Syrian hamster embryo cell line.叙利亚仓鼠胚胎细胞系中V-src基因扩增与致瘤表型的相关性
Cancer Res. 1987 Sep 1;47(17):4663-6.
9
Synergism of v-myc and v-Ha-ras in the in vitro neoplastic progression of murine lymphoid cells.v-myc与v-Ha-ras在小鼠淋巴细胞体外肿瘤进展中的协同作用。
Mol Cell Biol. 1986 Sep;6(9):3221-31. doi: 10.1128/mcb.6.9.3221-3231.1986.
10
Altered stem cell (CFU-S) function following infection of hematopoietic cells with a virus carrying V-src.携带V-src的病毒感染造血细胞后干细胞（CFU-S）功能的改变
Blood. 1986 Feb;67(2):398-405.

引用本文的文献

1
Expression of the LIM-homeobox gene LH2 generates immortalized steel factor-dependent multipotent hematopoietic precursors.LIM 同源框基因 LH2 的表达可产生永生化的、依赖于干细胞因子的多能造血前体细胞。
EMBO J. 1998 Oct 1;17(19):5744-56. doi: 10.1093/emboj/17.19.5744.
2
Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.通过Hox-2.4同源盒基因对小鼠骨髓单核细胞、巨核细胞和肥大细胞祖细胞进行条件性永生化。
EMBO J. 1993 Oct;12(10):3835-46. doi: 10.1002/j.1460-2075.1993.tb06062.x.
3
Developmentally-related changes in surface membrane glycopeptides of murine haemopoietic cells.

本文引用的文献

1
F4/80, a monoclonal antibody directed specifically against the mouse macrophage.F4/80，一种特异性针对小鼠巨噬细胞的单克隆抗体。
Eur J Immunol. 1981 Oct;11(10):805-15. doi: 10.1002/eji.1830111013.
2
Long-term marrow culture: an overview of techniques and experience.长期骨髓培养：技术与经验概述
Kroc Found Ser. 1984;18:57-96.
3
Hematopoietic cell transformation by a murine recombinant retrovirus containing the src gene of Rous sarcoma virus.含有劳氏肉瘤病毒src基因的鼠重组逆转录病毒对造血细胞的转化
小鼠造血细胞表面膜糖肽的发育相关变化
Biochem J. 1987 Mar 15;242(3):857-65. doi: 10.1042/bj2420857.
4
Metabolic properties of a homogeneous proteoglycan of a haemopoietic stem cell line, FDCP-mix.造血干细胞系FDCP-mix的一种同源蛋白聚糖的代谢特性
Biochem J. 1989 Jun 1;260(2):479-86. doi: 10.1042/bj2600479.
5
Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNase I-hypersensitive in hemopoietic progenitor cells.免疫球蛋白重链和CD3δ链基因增强子在造血祖细胞中对DNA酶I敏感。
Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3424-8. doi: 10.1073/pnas.89.8.3424.
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2374-8. doi: 10.1073/pnas.81.8.2374.
4
Effect of src infection on long-term marrow cultures: increased self-renewal of hemopoietic progenitor cells without leukemia.src感染对长期骨髓培养的影响：造血祖细胞自我更新增加而无白血病发生。
Cell. 1984 Mar;36(3):763-73. doi: 10.1016/0092-8674(84)90356-8.
5
Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses.识别禽肉瘤病毒转化蛋白的单克隆抗体的分离
J Virol. 1983 Nov;48(2):352-60. doi: 10.1128/JVI.48.2.352-360.1983.
6
Construction and isolation of a transforming murine retrovirus containing the src gene of Rous sarcoma virus.含有劳氏肉瘤病毒src基因的转化型鼠逆转录病毒的构建与分离。
J Virol. 1983 May;46(2):594-605. doi: 10.1128/JVI.46.2.594-605.1983.
7
Detection of a transforming gene product in cells transformed by Moloney murine sarcoma virus.在莫洛尼氏鼠肉瘤病毒转化的细胞中检测一种转化基因产物。
Cell. 1982 Jun;29(2):417-26. doi: 10.1016/0092-8674(82)90158-1.
8
Molecular mechanisms involved in morphological variation of avian sarcoma virus-infected rat cells.禽肉瘤病毒感染的大鼠细胞形态变异所涉及的分子机制。
Virology. 1982 Jan 30;116(2):428-40. doi: 10.1016/0042-6822(82)90137-4.
9
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules.禽肉瘤病毒环状DNA分子的分子克隆与特性分析
J Virol. 1980 Oct;36(1):50-61. doi: 10.1128/JVI.36.1.50-61.1980.
10
Infection of rat cells by avian sarcoma virus: factors affecting transformation and subsequent reversion.禽肉瘤病毒对大鼠细胞的感染：影响转化及后续回复突变的因素
Virology. 1980 Oct 30;106(2):217-33. doi: 10.1016/0042-6822(80)90246-9.