src感染的骨髓培养物中造血功能紊乱和多能干细胞克隆的产生是癌基因的间接或短暂效应。
Perturbed hemopoiesis and the generation of multipotential stem cell clones in src-infected bone marrow cultures is an indirect or transient effect of the oncogene.
作者信息
Wyke J A, Stoker A W, Searle S, Spooncer E, Simmons P, Dexter T M
出版信息
Mol Cell Biol. 1986 Mar;6(3):959-63. doi: 10.1128/mcb.6.3.959-963.1986.
Abstract
Multipotential stem cell lines, derived specifically from long-term bone marrow cultures infected with a recombinant retrovirus carrying v-src, lack v-src. Stable consequences thus result from transient actions or indirect effects of v-src on other cells, with the latter possibility being favored by its mosaic expression in marrow cultures.
摘要
多能干细胞系是从感染携带v-src的重组逆转录病毒的长期骨髓培养物中特异性衍生而来的，这些细胞系不含v-src。因此，稳定的结果源于v-src对其他细胞的瞬时作用或间接影响，后一种可能性因其在骨髓培养物中的镶嵌表达而更受青睐。
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