藜芦碱的药理作用：现状
Pharmacological Effects of Verticine: Current Status.
作者信息
Yin Zhenhua, Zhang Juanjuan, Guo Qingfeng, Chen Lin, Zhang Wei, Kang Wenyi
机构信息
Zhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450063, China.
Henan Joint International Research Laboratory of Drug Discovery of Small Molecules, Zhengzhou 450063, China.
出版信息
Evid Based Complement Alternat Med. 2019 Mar 7;2019:2394605. doi: 10.1155/2019/2394605. eCollection 2019.
Verticine is the major bioactive constituent of as a kind of Traditional Chinese Medicine. Pharmacological researches have reported various benefits of verticine, including anticancer, anti-inflammatory, protecting against acute lung injury, tracheobronchial relaxation, antitussive, expectorant, sedative, and analgesic activities, in addition to inhibiting proliferation of cultured orbital fibroblast, angiotensin converting enzyme (ACE), and acetylcholinesterase (AChE) and inhibiting hERG potassium channels. The underlying mechanisms of verticine are still under investigation. This review will comprehensively summarize the metabolism, biological activities, and possible mechanism of verticine.
藜芦碱是一种中药的主要生物活性成分。药理研究报道了藜芦碱的多种益处，包括抗癌、抗炎、预防急性肺损伤、气管支气管舒张、镇咳、祛痰、镇静和镇痛活性，此外还能抑制培养的眼眶成纤维细胞、血管紧张素转换酶（ACE）和乙酰胆碱酯酶（AChE）的增殖以及抑制人乙醚敏感钾通道（hERG）。藜芦碱的潜在机制仍在研究中。本综述将全面总结藜芦碱的代谢、生物活性及可能机制。
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