Liang Yingying, Liu Baoyi, Xiao Yu, Zeng Xiaomin, Wu Guanrong, Du Zijing, Fang Ying, Hu Yijun, Yang Xiaohong, Yu Honghua
Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
Front Aging Neurosci. 2022 Jul 4;14:834560. doi: 10.3389/fnagi.2022.834560. eCollection 2022.
To investigate retinal neurovascular structural changes in patients with ischemic stroke (IS) using optical coherence tomography angiography (OCTA).
The cross-sectional study was conducted in Guangdong Provincial People's Hospital, China, consisting of 159 eyes from IS patients and 109 eyes from age-matched control subjects. Retinal microvascular parameters including the vessel density (VD) of the superficial capillary plexus (SCP), deep capillary plexus (DCP) and radial peripapillary capillary (RPC), and neural parameters such as ganglion cell complex thickness (GCCt) and retinal nerve fibre layer thickness (RNFLt) were measured by OCTA.
The VD of SCP and DCP in the macular area were significantly reduced in IS patients compared to the control group (all < 0.001). The VD of RPC at the optic disc was also significantly reduced in IS patients (all < 0.05). IS patients showed reduced GCCt and RNFLt and increased GCC focal loss volume and global loss volume compared with the controls (all < 0.05). Among patients with IS, the parafovea SCP VD was positively correlated with GCCt ( = 0.346-0.408, all < 0.001) but not with DCP VD (all > 0.1). In the optic disc region, the whole image RPC VD was positively correlated with mean RNFLt ( = 0.467-0.548, all < 0.001).
Reduction of retinal VD, GCCt and RNFLt was observed in patients with IS. The parafovea SCP VD and RPC VD were positively correlated with GCCt and RNFLt, respectively.
采用光学相干断层扫描血管造影（OCTA）研究缺血性卒中（IS）患者的视网膜神经血管结构变化。
本横断面研究在中国广东省人民医院进行，纳入159例IS患者的眼睛和109例年龄匹配的对照者的眼睛。通过OCTA测量视网膜微血管参数，包括浅表毛细血管丛（SCP）、深层毛细血管丛（DCP）和视乳头周围放射状毛细血管（RPC）的血管密度（VD），以及神经参数，如神经节细胞复合体厚度（GCCt）和视网膜神经纤维层厚度（RNFLt）。
与对照组相比，IS患者黄斑区SCP和DCP的VD显著降低（均P<0.001）。IS患者视盘处RPC的VD也显著降低（均P<0.05）。与对照组相比，IS患者的GCCt和RNFLt降低，GCC局灶性损失体积和整体损失体积增加（均P<0.05）。在IS患者中，黄斑旁SCP的VD与GCCt呈正相关（r=0.3460.408，均P<0.001），但与DCP的VD无关（均P>0.1）。在视盘区域，全图像RPC的VD与平均RNFLt呈正相关（r=0.4670.548，均P<0.001）。
观察到IS患者视网膜VD、GCCt和RNFLt降低。黄斑旁SCP的VD和RPC的VD分别与GCCt和RNFLt呈正相关。
