Feldrihan Vasile, Benea Andreea, Junie Monica Lia
Functional Biosciences, Immunology and Allergy Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Immunology Laboratory of Prof. Dr. O. Fodor Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.
Med Pharm Rep. 2019 Jan;92(1):87-90. doi: 10.15386/cjmed-996. Epub 2019 Jan 15.
Clinical description of a patient diagnosed with chronic hepatitis C virus infection, which associated a rare anti-cytoplasmic pattern, known as "Rods and Ring".
Clinical case report.
A 76-year old female patient with chronic hepatitis C virus infection under treatment for several months with pegylated Interferon-Ribavirin (started eight months ago) presented for clinical and biological evaluation of the therapeutic response.
This is the first reported clinical case of a patient with cytoplasmic filamentous rods and rings autoantibodies associated with chronic hepatis C from the Clinical Hospital IRGH Prof. Dr. O. Fodor Cluj-Napoca, Romania. The presence of these antibodies appears to be triggered by antiviral therapy. Although these are newly identified antibodies, they could be used as serological markers for detecting patients at risk of developing associated autoimmune pathologies or nonresponders to the antiviral therapy. Likewise, their detection could identify patients with occult hepatitis C infection.
对一名被诊断为慢性丙型肝炎病毒感染的患者进行临床描述，该患者伴有一种罕见的抗细胞质模式，即“杆状和环状”。
临床病例报告。
一名76岁的女性慢性丙型肝炎病毒感染患者，接受聚乙二醇化干扰素 - 利巴韦林治疗数月（八个月前开始），前来进行治疗反应的临床和生物学评估。
这是罗马尼亚克鲁日 - 纳波卡IRGH教授O. Fodor临床医院首次报告的一例与慢性丙型肝炎相关的细胞质丝状杆状和环状自身抗体患者的临床病例。这些抗体的出现似乎是由抗病毒治疗引发的。尽管这些是新发现的抗体，但它们可作为血清学标志物，用于检测有发生相关自身免疫性疾病风险的患者或对抗病毒治疗无反应者。同样，对它们的检测可识别隐匿性丙型肝炎感染患者。
