Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Cell Biochem. 2019 Aug;120(8):13965-13973. doi: 10.1002/jcb.28671. Epub 2019 Apr 7.
Long noncoding RNAs (lncRNA) regulate expressions of several cancer-related genes and pathways. Expression profiling of lncRNAs would pave the way for identification of dysregulated pathways in cancer. We assessed expression of FAS-anti sense 1 (FAS-AS1), Taurine Upregulated 1 (TUG1), OPA-interacting protein 5-AS1 (OIP5 -AS1), nuclear-enriched abundant transcript 1 (NEAT1), and highly upregulated in liver cancer (HULC) in breast tumor tissues and adjacent noncancerous tissues (ANCTs). TUG1 was downregulated in tumoral tissues. We found associations between TUG1 expression and mitotic rate, NEAT1 expression and breast feeding duration as well as FAS-AS1 and OPI5 expressions and menarche age. A combination of transcript levels of all genes had 88.5% sensitivity and 42.3% specificity in breast cancer diagnosis. The current study provides evidence for the contribution of lncRNAs in breast cancer in relation to reproductive factors and tumor characteristics.
长链非编码 RNA（lncRNA）调节几种癌症相关基因和途径的表达。lncRNA 的表达谱分析将为鉴定癌症中失调的途径铺平道路。我们评估了 FAS-反义 1（FAS-AS1）、牛磺酸上调 1（TUG1）、OPA 相互作用蛋白 5-AS1（OIP5-AS1）、核富集丰富转录本 1（NEAT1）和肝癌中高表达（HULC）在乳腺癌组织和相邻非癌组织（ANCT）中的表达。TUG1 在肿瘤组织中下调。我们发现 TUG1 表达与有丝分裂率、NEAT1 表达与哺乳持续时间以及 FAS-AS1 和 OPI5 表达与初潮年龄之间存在关联。所有基因转录本水平的组合在乳腺癌诊断中具有 88.5%的敏感性和 42.3%的特异性。本研究为 lncRNA 在与生殖因素和肿瘤特征相关的乳腺癌中的作用提供了证据。
