a Departments of Obstetrics and Gynecology, General Hospital, Tianjin Medical University , Tianjin , China.
Gynecol Endocrinol. 2019 Sep;35(9):807-810. doi: 10.1080/09513590.2019.1597343. Epub 2019 Apr 7.
Kisspeptin has been shown to participate in the regulation of pituitary hormone secretion and energy metabolism. In PCOS patients, there are disorders in pituitary hormone secretion and energy metabolism. The aim of this study was to investigate the serum kisspeptin and its relationship with abnormal metabolism in PCOS. This restrospective case-control study included 73 cases with PCOS and 63 control cases. All subjects were divided into obese and nonobese groups based on BMI. The serum kisspeptin levels, Cor, DHEA-S, plasma concentrations of glucose were tested. We found that the level of kisspeptin in PCOS group was higher than it in control group. The kisspeptin levels in nonobese PCOS group increased most obviously over than the other groups. The kisspeptin levels of all the subjects were positively correlated with LH levels, negatively correlated with the glucose-AUC, the insulin-AUC, and triglyceride levels. The findings of this study suggest that kisspeptin may play an important role in ovulation disorders in PCOS patients through regulating the level of LH and it could regulate the body's energy metabolism by regulating glucose and lipid metabolism.
kisspeptin 参与调节垂体激素分泌和能量代谢。在 PCOS 患者中，存在垂体激素分泌和能量代谢紊乱。本研究旨在探讨 PCOS 患者血清 kisspeptin 及其与代谢异常的关系。本回顾性病例对照研究纳入 73 例 PCOS 患者和 63 例对照患者。所有患者均根据 BMI 分为肥胖组和非肥胖组。检测血清 kisspeptin、Cor、DHEA-S、血浆葡萄糖浓度。结果发现，PCOS 组血清 kisspeptin 水平高于对照组，非肥胖 PCOS 组升高最明显。所有患者 kisspeptin 水平与 LH 水平呈正相关，与葡萄糖 AUC、胰岛素 AUC、甘油三酯水平呈负相关。本研究结果提示，kisspeptin 可能通过调节 LH 水平在 PCOS 患者排卵障碍中发挥重要作用，并通过调节糖脂代谢调节机体能量代谢。
